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    Trim2 tripartite motif-containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 80890, updated on 12-May-2024

    Summary

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    Official Symbol
    Trim2provided by MGI
    Official Full Name
    tripartite motif-containing 2provided by MGI
    Primary source
    MGI:MGI:1933163
    See related
    Ensembl:ENSMUSG00000027993 AllianceGenome:MGI:1933163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    narf; mKIAA0517
    Summary
    Enables ubiquitin protein ligase activity. Involved in regulation of neuron apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 15.0), cerebellum adult (RPKM 13.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 37.48 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84067746..84215659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84160439..84308352, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3440 Neighboring gene predicted gene, 30458 Neighboring gene STARR-positive B cell enhancer ABC_E7917 Neighboring gene STARR-positive B cell enhancer ABC_E9214 Neighboring gene meiotic nuclear divisions 1 Neighboring gene STARR-positive B cell enhancer ABC_E1020 Neighboring gene STARR-seq mESC enhancer starr_08077 Neighboring gene STARR-seq mESC enhancer starr_08078 Neighboring gene ribosomal protein L36a pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:84032505-84032806 Neighboring gene nuclear encoded tRNA glycine 9 (anticodon GCC) Neighboring gene predicted gene, 40078 Neighboring gene STARR-positive B cell enhancer ABC_E3441 Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene FH2 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A recessive Trim2 mutation causes an axonal neuropathy in mice. Li JJ, et al. Neurobiol Dis, 2020 Jul. PMID 32205255
    2. Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. Sarute N, et al. PLoS Pathog, 2021 Jun. PMID 34097709, Free PMC Article
    3. TRIM2, a novel member of the antiviral family, limits New World arenavirus entry. Sarute N, et al. PLoS Biol, 2019 Feb. PMID 30726215, Free PMC Article
    4. The E3-ubiquitin ligase TRIM2 regulates neuronal polarization. Khazaei MR, et al. J Neurochem, 2011 Apr. PMID 20796172
    5. A Chromatin Accessibility Atlas of the Developing Human Telencephalon. Markenscoff-Papadimitriou E, et al. Cell, 2020 Aug 6. PMID 32610082, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis.
      Title: TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis.
    2. TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
      Title: TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
    3. a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance.
      Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
    4. Trim2 has an important function in the regulation of axon outgrowth during development.
      Title: The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.
    5. TRIM2 is an ubiquitin ligase and point to a mechanism regulating neurofilament light subunit metabolism through an ubiquitination pathway that, if deregulated, triggers neurodegeneration
      Title: Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0517

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tripartite motif-containing protein 2
    Names
    E3 ubiquitin-protein ligase TRIM2
    RING-type E3 ubiquitin transferase TRIM2
    neural activity-related ring finger protein
    tripartite motif protein 2
    tripartite motif protein TRIM2
    NP_001258654.1
    NP_001258655.1
    NP_001258656.1
    NP_001258657.1
    NP_109631.2
    XP_011238598.1
    XP_011238599.1
    XP_011238600.1
    XP_011238601.1
    XP_011238602.1
    XP_011238603.1
    XP_011238604.1
    XP_011238605.1
    XP_011238606.1
    XP_011238607.1
    XP_017175302.1
    XP_017175303.1
    XP_017175304.1
    XP_030108777.1
    XP_030108778.1
    XP_030108779.1
    XP_036019315.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271725.1 → NP_001258654.1  tripartite motif-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK147275, CA751006, CJ100776
      Consensus CDS
      CCDS71257.1
      UniProtKB/TrEMBL
      E9QKC6, Q3URK9
      Related
      ENSMUSP00000049902.5, ENSMUST00000054990.11
      Conserved Domains (7) summary
      smart00502
      Location:187 → 313
      BBC; B-Box C-terminal domain
      smart00336
      Location:139 → 180
      BBOX; B-Box-type zinc finger
      smart00557
      Location:351 → 447
      IG_FLMN; Filamin-type immunoglobulin domains
      COG3391
      Location:516 → 761
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00162
      Location:49 → 92
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14960
      Location:497 → 770
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      pfam00630
      Location:351 → 444
      Filamin; Filamin/ABP280 repeat

    2. NM_001271726.1 → NP_001258655.1  tripartite motif-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001258655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 5 encode the same isoform (2).
      Source sequence(s)
      AC102235, AK147275, CA751006, CD802800
      Consensus CDS
      CCDS71256.1
      UniProtKB/Swiss-Prot
      Q3UHP5, Q5DU27, Q8C981, Q9ESN6
      UniProtKB/TrEMBL
      Q3TPI3
      Related
      ENSMUSP00000103320.2, ENSMUST00000107692.8
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    3. NM_001271727.1 → NP_001258656.1  tripartite motif-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001258656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 5 encode the same isoform (2).
      Source sequence(s)
      AK147275, CA751006, CJ105472
      Consensus CDS
      CCDS71256.1
      UniProtKB/Swiss-Prot
      Q3UHP5, Q5DU27, Q8C981, Q9ESN6
      UniProtKB/TrEMBL
      Q3TPI3
      Related
      ENSMUSP00000103319.2, ENSMUST00000107691.8
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    4. NM_001271728.1 → NP_001258657.1  tripartite motif-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001258657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 5 encode the same isoform (2).
      Source sequence(s)
      AK147275, BC058961, CA751006
      Consensus CDS
      CCDS71256.1
      UniProtKB/Swiss-Prot
      Q3UHP5, Q5DU27, Q8C981, Q9ESN6
      UniProtKB/TrEMBL
      Q3TPI3
      Related
      ENSMUSP00000069922.7, ENSMUST00000065380.13
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    5. NM_030706.3 → NP_109631.2  tripartite motif-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_109631.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and differs in the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK147275, CA751006, CD803806
      Consensus CDS
      CCDS17437.2
      UniProtKB/TrEMBL
      Q3UHH4, Q3URK9
      Related
      ENSMUSP00000103323.3, ENSMUST00000107695.9
      Conserved Domains (5) summary
      smart00502
      Location:178 → 304
      BBC; B-Box C-terminal domain
      smart00557
      Location:342 → 438
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:488 → 761
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:37 → 82
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:132 → 173
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      84067746..84215659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252918.1 → XP_030108778.1  tripartite motif-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:179 → 305
      BBC; B-Box C-terminal domain
      smart00557
      Location:343 → 439
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:489 → 762
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:38 → 83
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:133 → 174
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    2. XM_011240298.3 → XP_011238600.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:179 → 305
      BBC; B-Box C-terminal domain
      smart00557
      Location:343 → 439
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:489 → 766
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:38 → 83
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:133 → 174
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    3. XM_017319814.3 → XP_017175303.1  tripartite motif-containing protein 2 isoform X8

      UniProtKB/Swiss-Prot
      Q3UHP5, Q5DU27, Q8C981, Q9ESN6
      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    4. XM_011240301.4 → XP_011238603.1  tripartite motif-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011238603.1

      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    5. XM_017319813.3 → XP_017175302.1  tripartite motif-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:183 → 309
      BBC; B-Box C-terminal domain
      smart00557
      Location:347 → 443
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:493 → 766
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:42 → 87
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:137 → 178
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    6. XM_011240302.3 → XP_011238604.1  tripartite motif-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011238604.1

      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    7. XM_030252917.2 → XP_030108777.1  tripartite motif-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:183 → 309
      BBC; B-Box C-terminal domain
      smart00557
      Location:347 → 443
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:493 → 766
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:42 → 87
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:137 → 178
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    8. XM_011240297.3 → XP_011238599.1  tripartite motif-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:183 → 309
      BBC; B-Box C-terminal domain
      smart00557
      Location:347 → 443
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:493 → 770
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:42 → 87
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:137 → 178
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    9. XM_011240296.2 → XP_011238598.1  tripartite motif-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:187 → 313
      BBC; B-Box C-terminal domain
      smart00557
      Location:351 → 447
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:497 → 774
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:46 → 91
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:141 → 182
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    10. XM_011240300.4 → XP_011238602.1  tripartite motif-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011238602.1

      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    11. XM_011240299.4 → XP_011238601.1  tripartite motif-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      Q3URK9
      Conserved Domains (5) summary
      smart00502
      Location:178 → 304
      BBC; B-Box C-terminal domain
      smart00557
      Location:342 → 438
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:488 → 765
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:37 → 82
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:132 → 173
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    12. XM_017319815.3 → XP_017175304.1  tripartite motif-containing protein 2 isoform X9

      Conserved Domains (2) summary
      smart00557
      Location:49 → 145
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:195 → 468
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

    13. XM_011240304.4 → XP_011238606.1  tripartite motif-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011238606.1

      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    14. XM_030252919.2 → XP_030108779.1  tripartite motif-containing protein 2 isoform X8

      UniProtKB/Swiss-Prot
      Q3UHP5, Q5DU27, Q8C981, Q9ESN6
      UniProtKB/TrEMBL
      Q3TPI3
      Related
      ENSMUSP00000103321.3, ENSMUST00000107693.9
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    15. XM_036163422.1 → XP_036019315.1  tripartite motif-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    16. XM_011240303.4 → XP_011238605.1  tripartite motif-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011238605.1

      UniProtKB/TrEMBL
      Q3TPI3
      Conserved Domains (5) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    17. XM_011240305.1 → XP_011238607.1  tripartite motif-containing protein 2 isoform X10

      Conserved Domains (4) summary
      smart00502
      Location:161 → 235
      BBC; B-Box C-terminal domain
      cd00162
      Location:23 → 63
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:115 → 156
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:20 → 65
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESN6.1 GenPept UniProtKB/Swiss-Prot:Q9ESN6

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