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    RAPGEF2 Rap guanine nucleotide exchange factor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704717, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RAPGEF2provided by VGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 2provided by VGNC
    Primary source
    VGNC:VGNC:76493
    See related
    Ensembl:ENSMMUG00000010581
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RAPGEF2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (156687547..156947263)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (159084611..159345488)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene proteasome activator complex subunit 2 pseudogene Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 2
    Names
    Rap guanine nucleotide exchange factor (GEF) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      156687547..156947263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015139430.2 → XP_014994916.2  rap guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q4X6, A0A1D5Q7Y4
      Related
      ENSMMUP00000044151.2, ENSMMUT00000061925.2
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    2. XM_028848849.1 → XP_028704682.1  rap guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q4X6
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    3. XM_028848848.1 → XP_028704681.1  rap guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5Q4X6
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_015139432.2 → XP_014994918.2  rap guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZQE2
      Related
      ENSMMUP00000067856.1, ENSMMUT00000104912.1
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_015139431.2 → XP_014994917.2  rap guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZQE2
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_028848850.1 → XP_028704683.1  rap guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A1D5Q4X6
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_028848851.1 → XP_028704684.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZEW2, A0A5F8AMC8
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_028848853.1 → XP_028704686.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZEW2, A0A5F8AMC8
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_028848854.1 → XP_028704687.1  rap guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A5F7ZEW2
      Conserved Domains (6) summary
      smart00100
      Location:175 → 290
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:306 → 419
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:752 → 977
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:423 → 503
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:443 → 567
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:647 → 729
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_028848855.1 → XP_028704688.1  rap guanine nucleotide exchange factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A5F7ZEW2
      Related
      ENSMMUP00000072902.1, ENSMMUT00000083044.1
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_028848852.1 → XP_028704685.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZEW2, A0A5F8AMC8
      Related
      ENSMMUP00000079076.1, ENSMMUT00000085237.1
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_028848856.1 → XP_028704689.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A5F7ZEW2
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_028848857.1 → XP_028704690.1  rap guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      A0A5F7ZEW2, F7CHR7
      Related
      ENSMMUP00000013870.3, ENSMMUT00000014805.4
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    14. XM_001093090.4 → XP_001093090.3  rap guanine nucleotide exchange factor 2 isoform X13

      UniProtKB/TrEMBL
      A0A5F7ZEW2, A0A8J8XLU3, G7MS85, H9G2C2
      Conserved Domains (6) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:404 → 528
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    15. XM_028848858.1 → XP_028704691.1  rap guanine nucleotide exchange factor 2 isoform X12

      UniProtKB/TrEMBL
      A0A5F7ZEW2
      Conserved Domains (6) summary
      smart00100
      Location:117 → 232
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:248 → 361
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:694 → 919
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:365 → 445
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:385 → 509
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:589 → 671
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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