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    Zbtb49 zinc finger and BTB domain containing 49 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305428, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Zbtb49provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 49provided by RGD
    Primary source
    RGD:1306733
    See related
    Ensembl:ENSRNOG00000005633 AllianceGenome:RGD:1306733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp509; Znf509
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleus. Predicted to be active in nucleoplasm. Orthologous to human ZBTB49 (zinc finger and BTB domain containing 49). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 27.8), Adrenal (RPKM 27.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb49 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (76802988..76835573)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (72590692..72612404)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (77322014..77343736)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481772 Neighboring gene Ly1 antibody reactive Neighboring gene uncharacterized LOC120096634 Neighboring gene neuronal vesicle trafficking associated 1 Neighboring gene syntaxin 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress. Jeon BN, et al. Nucleic Acids Res, 2014 Oct. PMID 25245946, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 49
    Names
    zinc finger protein 509

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394682.2 → NP_001381611.1  zinc finger and BTB domain-containing protein 49 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JT85
      Related
      ENSRNOP00000068611.1, ENSRNOT00000088600.2
      Conserved Domains (5) summary
      PHA03247
      Location:121 → 300
      PHA03247; large tegument protein UL36; Provisional
      COG5048
      Location:400 → 578
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:502 → 522
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18233
      Location:7 → 118
      BTB_POZ_ZBTB49; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49)
      pfam00096
      Location:388 → 410
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001401386.1 → NP_001388315.1  zinc finger and BTB domain-containing protein 49 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    3. NM_001401387.1 → NP_001388316.1  zinc finger and BTB domain-containing protein 49 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RNA

    1. NR_174703.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    2. NR_174704.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      Related
      ENSRNOT00000041639.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      76802988..76835573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273141.1 → XP_063129211.1  zinc finger and BTB domain-containing protein 49 isoform X1

    2. XM_063273142.1 → XP_063129212.1  zinc finger and BTB domain-containing protein 49 isoform X2

      UniProtKB/TrEMBL
      A6IJU2, D4A8F0
    Nucleotide Protein Strain
    Heading Accession and Version

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