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    Vwce von Willebrand factor C and EGF domains [ Mus musculus (house mouse) ]

    Gene ID: 71768, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Vwceprovided by MGI
    Official Full Name
    von Willebrand factor C and EGF domainsprovided by MGI
    Primary source
    MGI:MGI:1919018
    See related
    Ensembl:ENSMUSG00000043789 AllianceGenome:MGI:1919018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300015B04Rik
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Is expressed in left lung; mandible; maxilla; orbito-sphenoid; and right lung. Orthologous to human VWCE (von Willebrand factor C and EGF domains). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 7.7), duodenum adult (RPKM 7.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 6.87 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10611582..10643577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10634218..10666213)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 138 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene STARR-seq mESC enhancer starr_45554 Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene pepsinogen 5, group I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Yang H, et al. Cell, 2012 Apr 27. PMID 22541431
    2. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor C and EGF domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027913.2 → NP_082189.1  von Willebrand factor C and EGF domain-containing protein precursor

      See identical proteins and their annotated locations for NP_082189.1

      Status: VALIDATED

      Source sequence(s)
      AC132247
      Consensus CDS
      CCDS50390.1
      UniProtKB/Swiss-Prot
      E9QME6, Q3U515
      Related
      ENSMUSP00000056958.8, ENSMUST00000055115.9
      Conserved Domains (4) summary
      smart00179
      Location:220 → 262
      EGF_CA; Calcium-binding EGF-like domain
      smart00214
      Location:564 → 617
      VWC; von Willebrand factor (vWF) type C domain
      pfam12662
      Location:200 → 223
      cEGF; Complement Clr-like EGF-like
      cl17735
      Location:493 → 551
      VWC; von Willebrand factor type C domain

    RNA

    1. NR_153778.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132247

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10611582..10643577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527347.4 → XP_006527410.1  von Willebrand factor C and EGF domain-containing protein isoform X1

      Conserved Domains (5) summary
      smart00179
      Location:220 → 262
      EGF_CA; Calcium-binding EGF-like domain
      smart00214
      Location:564 → 617
      VWC; von Willebrand factor (vWF) type C domain
      PHA03247
      Location:717 → 916
      PHA03247; large tegument protein UL36; Provisional
      cl17735
      Location:493 → 551
      VWC; von Willebrand factor type C domain
      pfam12662
      Location:200 → 223
      cEGF; Complement Clr-like EGF-like

    2. XM_006527348.4 → XP_006527411.1  von Willebrand factor C and EGF domain-containing protein isoform X2

      Conserved Domains (5) summary
      smart00179
      Location:220 → 262
      EGF_CA; Calcium-binding EGF-like domain
      smart00214
      Location:613 → 668
      VWC; von Willebrand factor (vWF) type C domain
      PHA03247
      Location:707 → 914
      PHA03247; large tegument protein UL36; Provisional
      cl17735
      Location:493 → 551
      VWC; von Willebrand factor type C domain
      pfam12662
      Location:200 → 223
      cEGF; Complement Clr-like EGF-like

    3. XM_006527349.4 → XP_006527412.1  von Willebrand factor C and EGF domain-containing protein isoform X3

      Conserved Domains (2) summary
      smart00214
      Location:111 → 164
      VWC; von Willebrand factor (vWF) type C domain
      PHA03247
      Location:262 → 473
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_003952821.1 RNA Sequence

    2. XR_386516.4 RNA Sequence

    3. XR_386514.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U515.2 GenPept UniProtKB/Swiss-Prot:Q3U515

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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