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    UBOX5 U-box domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 22888, updated on 5-Mar-2024

    Summary

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    Official Symbol
    UBOX5provided by HGNC
    Official Full Name
    U-box domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:17777
    See related
    Ensembl:ENSG00000185019 MIM:619675; AllianceGenome:HGNC:17777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UIP5; RNF37; hUIP5; UBCE7IP5
    Summary
    This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
    Expression
    Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    20p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3107573..3159865, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3138473..3190765, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3088219..3140511, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3073228-3073728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3073729-3074229 Neighboring gene arginine vasopressin Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12614 Neighboring gene uncharacterized LOC107985414

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ancient origin of animal U-box ubiquitin ligases. Marín I. BMC Evol Biol, 2010 Oct 27. PMID 20979629, Free PMC Article
    2. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. Pringa E, et al. J Biol Chem, 2001 Jun 1. PMID 11274149
    3. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. Martinez-Noel G, et al. FEBS Lett, 1999 Jul 9. PMID 10431818
    4. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
    5. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Hatakeyama S, et al. Genes Cells, 2004 Jun. PMID 15189447

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0860

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 37
    Names
    RING-type E3 ubiquitin transferase RNF37
    U-box domain-containing protein 5
    ubcM4-interacting protein 5
    ubiquitin conjugating enzyme 7 interacting protein 5
    NP_001254513.1
    NP_055763.1
    NP_955447.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267584.2 → NP_001254513.1  RING finger protein 37 isoform c

      See identical proteins and their annotated locations for NP_001254513.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a translational frameshift, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL121891, BC064544, BM992259, DA101925
      UniProtKB/TrEMBL
      Q53GQ5
      Conserved Domains (1) summary
      pfam04564
      Location:259 → 337
      U-box; U-box domain

    2. NM_014948.4 → NP_055763.1  RING finger protein 37 isoform a

      See identical proteins and their annotated locations for NP_055763.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB020667, AL121891, BM992259
      Consensus CDS
      CCDS13046.1
      UniProtKB/Swiss-Prot
      O94941, Q6IAR5, Q86X87, Q9H4J2
      UniProtKB/TrEMBL
      Q53GQ5
      Related
      ENSP00000217173.2, ENST00000217173.7
      Conserved Domains (2) summary
      cd16537
      Location:482 → 528
      RING-HC_RNF37; RING finger, HC subclass, found in RING finger protein 37 (RNF37)
      cd16660
      Location:260 → 312
      RING-Ubox_RNF37; U-box domain, a modified RING finger, found in RING finger protein 37 (RNF37)

    3. NM_199415.3 → NP_955447.1  RING finger protein 37 isoform b

      See identical proteins and their annotated locations for NP_955447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL121891, BC046122, BM992259
      Consensus CDS
      CCDS13047.1
      UniProtKB/TrEMBL
      Q53HL0
      Related
      ENSP00000311726.3, ENST00000348031.6
      Conserved Domains (2) summary
      pfam04564
      Location:259 → 337
      U-box; U-box domain
      pfam14634
      Location:432 → 475
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3107573..3159865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3138473..3190765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94941.1 GenPept UniProtKB/Swiss-Prot:O94941

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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