Il17rb interleukin 17 receptor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il17rbprovided by MGI
Official Full Name: interleukin 17 receptor Bprovided by MGI
Primary source: MGI:MGI:1355292
See related: Ensembl:ENSMUSG00000015966 AllianceGenome:MGI:1355292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Evi27; Il17br; IL-17ER; IL17RH1; IL-17Rh1
Summary: Predicted to enable interleukin-17 receptor activity. Acts upstream of or within positive regulation of inflammatory response; positive regulation of interleukin-13 production; and positive regulation of interleukin-5 production. Located in cell surface and cytoplasm. Is expressed in thymus primordium. Orthologous to human IL17RB (interleukin 17 receptor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 14.9), subcutaneous fat pad adult (RPKM 7.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 18.39 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (29718125..29730853, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (29996168..30008896, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neonatal-derived IL-17 producing dermal gammadelta T cells are required to prevent spontaneous atopic dermatitis.
Title: Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis.
The authors show that interleukin-17 can reduce lipoprotein trafficking and increase vascular stiffness by remodeling collagen.
Title: Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.
Il17rb was distinctively expressed by Dclk1+ mouse intestinal tumor cells. Using Il17rb-CreERT2-IRES-EGFP mice, study shows that Il17rb marked intestinal cancer stem cell (CSCs) in an IL13-dependent manner. Furthermore, long-term ablation of Il17rb-expressing CSCs strongly suppressed the tumor growth in vivo.
Title: Lineage tracing and targeting of IL17RB(+) tuft cell-like human colorectal cancer stem cells.
Effective anti-helminth immunity during chronic infection requires an innate effector cell population that is synergistically activated by the combination of interleukin 4 receptor alpha (IL-4Ralpha) and IL-25R (Il17rb)-signaling.
Title: Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion.
IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease
Title: IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease.
Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells.
Title: Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
Title: Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
IL-17RB-positive cells in the bone marrow also express CD11B, GR1, and c-kit, potentially suggesting a maturation of the bone marrow cell once it enters the inflamed lung.
Title: Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease.
IL-17RB(+) iNKT cells were detected in the lungs of wild-type mice, and induction of airway hyperreactivity by intranasal administration of IL-25 was significantly impaired in iNKT cell-deficient mice
Title: Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB.
Results identify a novel subset of natural killer T cells that expresses the interleukin 17 receptor B (IL-17RB) for IL-25 and is essential for the induction of the airway hypersensitive reaction.
Title: A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables interleukin-17 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: interleukin-17 receptor B

Names: IL-17 receptor B; IL-17 receptor homolog 1; IL-17B receptor; IL-17RB; ecotropic viral integration site 27; interleukin 17B receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019583.3 → NP_062529.2 interleukin-17 receptor B precursor

See identical proteins and their annotated locations for NP_062529.2

Status: PROVISIONAL

Source sequence(s)

AK045627

Consensus CDS

CCDS36845.1

UniProtKB/Swiss-Prot

Q9JIP2, Q9JIP3

UniProtKB/TrEMBL

D3Z4T0, Q543U7

Related

ENSMUSP00000016110.7, ENSMUST00000016110.13

Conserved Domains (2) summary

pfam08357
Location:329 → 476

SEFIR; SEFIR domain

pfam16556
Location:33 → 175

IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

29718125..29730853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247884.1 → XP_030103744.1 interleukin-17 receptor B isoform X1

Conserved Domains (1) summary

pfam08357
Location:102 → 249

SEFIR; SEFIR domain