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    Arhgef10 Rho guanine nucleotide exchange factor 10 [ Mus musculus (house mouse) ]

    Gene ID: 234094, updated on 4-May-2024

    Summary

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    Official Symbol
    Arhgef10provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 10provided by MGI
    Primary source
    MGI:MGI:2444453
    See related
    Ensembl:ENSMUSG00000071176 AllianceGenome:MGI:2444453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0294; 6430549H08Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be located in cytosol. Predicted to be active in centrosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 7.6), bladder adult (RPKM 6.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 7.59 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (14956405..15051085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (14906412..15001085)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DLG associated protein 2 Neighboring gene RIKEN cDNA C030037F17 gene Neighboring gene STARR-seq mESC enhancer starr_20794 Neighboring gene STARR-seq mESC enhancer starr_20795 Neighboring gene STARR-positive B cell enhancer ABC_E4989 Neighboring gene STARR-positive B cell enhancer mm9_chr8:14961480-14961780 Neighboring gene CLN8 transmembrane ER and ERGIC protein Neighboring gene STARR-positive B cell enhancer ABC_E4990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:14996167-14996320 Neighboring gene predicted gene, 35285 Neighboring gene STARR-seq mESC enhancer starr_20800 Neighboring gene predicted gene 16350 Neighboring gene predicted gene, 35149 Neighboring gene kelch repeat and BTB (POZ) domain containing 11 Neighboring gene predicted gene, 35340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impairment of social behaviors in Arhgef10 knockout mice. Lu DH, et al. Mol Autism, 2018. PMID 29456827, Free PMC Article
    2. ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation. Lu DH, et al. J Thromb Haemost, 2017 Oct. PMID 28799234
    3. Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. Verhoeven K, et al. Am J Hum Genet, 2003 Oct. PMID 14508709, Free PMC Article
    4. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Xue W, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566646, Free PMC Article
    5. Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, et al. Gene Expr Patterns, 2003 Jun. PMID 12799088

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0294

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 10
    Names
    Rho guanine nucleotide exchange factor (GEF) 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037736.2 → NP_001032825.1  rho guanine nucleotide exchange factor 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AK147669, BC059212, BC066074, CD774578
      Consensus CDS
      CCDS40241.1
      UniProtKB/TrEMBL
      Q3UGZ6
      Related
      ENSMUSP00000106424.3, ENSMUST00000110800.9
      Conserved Domains (2) summary
      pfam00621
      Location:366 → 544
      RhoGEF; RhoGEF domain
      cl17171
      Location:576 → 640
      PH-like; Pleckstrin homology-like domain

    2. NM_172751.3 → NP_766339.2  rho guanine nucleotide exchange factor 10 isoform a

      See identical proteins and their annotated locations for NP_766339.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AK147669, BC059212, BC066074, CD774578
      Consensus CDS
      CCDS40240.1
      UniProtKB/Swiss-Prot
      Q5DU38, Q80VH8, Q8BW76, Q8C033, Q922S7
      UniProtKB/TrEMBL
      Q3UGZ6
      Related
      ENSMUSP00000081225.6, ENSMUST00000084207.12
      Conserved Domains (3) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:862 → 1343
      WD40_2; WD40 repeated domain
      pfam19057
      Location:605 → 754
      PH_19; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      14956405..15051085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243425.2 → XP_030099285.1  rho guanine nucleotide exchange factor 10 isoform X7

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    2. XM_017312669.3 → XP_017168158.1  rho guanine nucleotide exchange factor 10 isoform X1

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:482 → 666
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:699 → 763
      PH-like; Pleckstrin homology-like domain

    3. XM_036153887.1 → XP_036009780.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:482 → 666
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:946 → 1427
      WD40_2; WD40 repeated domain
      pfam19057
      Location:689 → 838
      PH_19; PH domain

    4. XM_036153888.1 → XP_036009781.1  rho guanine nucleotide exchange factor 10 isoform X4

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:443 → 627
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:907 → 1427
      WD40_2; WD40 repeated domain
      pfam19057
      Location:650 → 799
      PH_19; PH domain

    5. XM_036153889.1 → XP_036009782.1  rho guanine nucleotide exchange factor 10 isoform X6

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:443 → 627
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:907 → 1388
      WD40_2; WD40 repeated domain
      pfam19057
      Location:650 → 799
      PH_19; PH domain

    6. XM_036153886.1 → XP_036009779.1  rho guanine nucleotide exchange factor 10 isoform X2

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:945 → 1465
      WD40_2; WD40 repeated domain
      pfam19057
      Location:688 → 837
      PH_19; PH domain

    7. XM_017312673.2 → XP_017168162.1  rho guanine nucleotide exchange factor 10 isoform X7

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    8. XM_006508771.5 → XP_006508834.1  rho guanine nucleotide exchange factor 10 isoform X7

      See identical proteins and their annotated locations for XP_006508834.1

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    9. XM_036153891.1 → XP_036009784.1  rho guanine nucleotide exchange factor 10 isoform X10

      UniProtKB/Swiss-Prot
      Q5DU38, Q80VH8, Q8BW76, Q8C033, Q922S7
      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:862 → 1343
      WD40_2; WD40 repeated domain
      pfam19057
      Location:605 → 754
      PH_19; PH domain

    10. XM_006508770.4 → XP_006508833.1  rho guanine nucleotide exchange factor 10 isoform X7

      See identical proteins and their annotated locations for XP_006508833.1

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    11. XM_030243426.1 → XP_030099286.1  rho guanine nucleotide exchange factor 10 isoform X11

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:359 → 543
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:576 → 640
      PH-like; Pleckstrin homology-like domain

    12. XM_006508772.3 → XP_006508835.1  rho guanine nucleotide exchange factor 10 isoform X8

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:397 → 581
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:614 → 678
      PH-like; Pleckstrin homology-like domain

    13. XM_036153892.1 → XP_036009785.1  rho guanine nucleotide exchange factor 10 isoform X12

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:397 → 581
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:861 → 1342
      WD40_2; WD40 repeated domain
      pfam19057
      Location:604 → 753
      PH_19; PH domain

    14. XM_036153893.1 → XP_036009786.1  rho guanine nucleotide exchange factor 10 isoform X13

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:358 → 542
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:822 → 1342
      WD40_2; WD40 repeated domain
      pfam19057
      Location:565 → 714
      PH_19; PH domain

    15. XM_036153894.1 → XP_036009787.1  rho guanine nucleotide exchange factor 10 isoform X15

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:358 → 542
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:822 → 1303
      WD40_2; WD40 repeated domain
      pfam19057
      Location:565 → 714
      PH_19; PH domain

    16. XM_006508768.4 → XP_006508831.1  rho guanine nucleotide exchange factor 10 isoform X5

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:422 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:639 → 703
      PH-like; Pleckstrin homology-like domain

    17. XM_017312672.2 → XP_017168161.1  rho guanine nucleotide exchange factor 10 isoform X14

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (2) summary
      cd00160
      Location:383 → 567
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:600 → 664
      PH-like; Pleckstrin homology-like domain

    18. XM_036153890.1 → XP_036009783.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      Q3UGZ6
      Conserved Domains (3) summary
      cd00160
      Location:421 → 605
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:885 → 1366
      WD40_2; WD40 repeated domain
      pfam19057
      Location:628 → 777
      PH_19; PH domain

    19. XM_006508773.5 → XP_006508836.1  rho guanine nucleotide exchange factor 10 isoform X16

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C033.2 GenPept UniProtKB/Swiss-Prot:Q8C033

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