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    PECR peroxisomal trans-2-enoyl-CoA reductase [ Homo sapiens (human) ]

    Gene ID: 55825, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PECRprovided by HGNC
    Official Full Name
    peroxisomal trans-2-enoyl-CoA reductaseprovided by HGNC
    Primary source
    HGNC:HGNC:18281
    See related
    Ensembl:ENSG00000115425 MIM:605843; AllianceGenome:HGNC:18281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TERP; DCRRP; PVIARL; HPDHASE; SDR29C1; HSA250303
    Summary
    Enables signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in phytol metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver (RPKM 14.1), fat (RPKM 7.2) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216029088..216081809, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216514519..216567213, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216903111..216946532, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 607 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17076 Neighboring gene uncharacterized LOC105373870 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216786644-216787283 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216787284-216787924 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:216792334-216792860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17078 Neighboring gene melanoregulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:216877329-216878096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216973795-216974416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17089 Neighboring gene Sharpr-MPRA regulatory regions 7837 and 8351 Neighboring gene transmembrane protein 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17092 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:217020960-217022159 Neighboring gene X-ray repair cross complementing 5 Neighboring gene DNA polymerase eta pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids. Hua T, et al. J Biol Chem, 2012 Aug 17. PMID 22745130, Free PMC Article
    2. Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b. Uchida Y, et al. J Biol Chem, 2021 Jan-Jun. PMID 33482198, Free PMC Article
    3. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. Gloerich J, et al. FEBS Lett, 2006 Apr 3. PMID 16546181
    4. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. Braastad CD, et al. Nucleic Acids Res, 2002 Apr 15. PMID 11937624, Free PMC Article
    5. TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import. Wang W, et al. J Cell Biol, 2017 Sep 4. PMID 28724525, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b.
      Title: Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b.
    2. Biochemical studies and structural analysis suggest that pDCRs can catalyze the shortening of six-carbon-long substrates in vitro.
      Title: Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
    4. Human trans-2-enoyl-CoA reductase (TER) is responsible for the reduction of phytenoyl-CoA to phytanoyl-CoA in peroxisomes.
      Title: Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of alcohol dependence.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phytol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phytol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in peroxisomal membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal trans-2-enoyl-CoA reductase
    Names
    2,4-dienoyl-CoA reductase-related protein
    DCR-RP
    pVI-ARL
    putative short chain alcohol dehydrogenase
    short chain dehydrogenase/reductase family 29C member 1
    NP_060911.2
    XP_047301062.1
    XP_047301063.1
    XP_047301064.1
    XP_054198979.1
    XP_054198980.1
    XP_054198981.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018441.6 → NP_060911.2  peroxisomal trans-2-enoyl-CoA reductase

      See identical proteins and their annotated locations for NP_060911.2

      Status: VALIDATED

      Source sequence(s)
      AC010686, AF212234, BU151224
      Consensus CDS
      CCDS33375.1
      UniProtKB/Swiss-Prot
      B2RE42, Q53TC4, Q6IAK9, Q9BY49, Q9NRD4, Q9NY60, Q9P1A4
      Related
      ENSP00000265322.7, ENST00000265322.8
      Conserved Domains (1) summary
      cd05369
      Location:16 → 267
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      216029088..216081809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445108.1 → XP_047301064.1  peroxisomal trans-2-enoyl-CoA reductase isoform X3

    2. XM_047445107.1 → XP_047301063.1  peroxisomal trans-2-enoyl-CoA reductase isoform X2

      Related
      ENSP00000395512.1, ENST00000442122.5

    3. XM_047445106.1 → XP_047301062.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

    RNA

    1. XR_007078553.1 RNA Sequence

    2. XR_007078552.1 RNA Sequence

    3. XR_001738847.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      216514519..216567213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343006.1 → XP_054198981.1  peroxisomal trans-2-enoyl-CoA reductase isoform X3

    2. XM_054343005.1 → XP_054198980.1  peroxisomal trans-2-enoyl-CoA reductase isoform X2

    3. XM_054343004.1 → XP_054198979.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

    RNA

    1. XR_008486457.1 RNA Sequence

    2. XR_008486456.1 RNA Sequence

    3. XR_008486455.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BY49.2 GenPept UniProtKB/Swiss-Prot:Q9BY49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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