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    GPR84 G protein-coupled receptor 84 [ Homo sapiens (human) ]

    Gene ID: 53831, updated on 17-Jun-2024

    Summary

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    Official Symbol
    GPR84provided by HGNC
    Official Full Name
    G protein-coupled receptor 84provided by HGNC
    Primary source
    HGNC:HGNC:4535
    See related
    Ensembl:ENSG00000139572 MIM:606383; AllianceGenome:HGNC:4535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EX33; GPCR4
    Summary
    Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bone marrow (RPKM 5.7), appendix (RPKM 3.3) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR84 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54350698..54364486, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54317281..54331118, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54756229..54758270, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene RNA, 7SL, cytoplasmic 744, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54750728-54751553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54751554-54752378 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:54752379-54753203 Neighboring gene GPR84, ZNF385A, ITGA5 and GTSF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6441 Neighboring gene zinc finger protein 385A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:54781074-54781708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:54781709-54782342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4529 Neighboring gene integrin subunit alpha 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54805235-54806017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54806018-54806799

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? Luscombe VB, et al. DNA Cell Biol, 2020 Nov. PMID 33001759
    2. Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Müller MM, et al. Sci Rep, 2017 Apr 12. PMID 28404994, Free PMC Article
    3. Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84. Nikaido Y, et al. J Biochem, 2015 May. PMID 25425658
    4. GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis. Dietrich PA, et al. Blood, 2014 Nov 20. PMID 25293777
    5. Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells. Peters A, et al. Pharmacol Res, 2022 Feb. PMID 34968686

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR84 in physiology-Many functions in many tissues.
      Title: GPR84 in physiology-Many functions in many tissues.
    2. Regulation of the pro-inflammatory G protein-coupled receptor GPR84.
      Title: Regulation of the pro-inflammatory G protein-coupled receptor GPR84.
    3. Function and regulation of GPR84 in human neutrophils.
      Title: Function and regulation of GPR84 in human neutrophils.
    4. Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
      Title: Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
    5. Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.
      Title: Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.
    6. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
      Title: Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
    7. The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
      Title: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
    8. Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
      Title: Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
    9. 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?
      Title: 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?
    10. Has a strong stimulatory effect on the expression of cytokine and chemokine genes, particularly CSF3, and on the expression of GPR84, a pro-inflammatory fatty acid receptor.
      Title: IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables urotensin II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 84
    Names
    inflammation-related G protein-coupled receptor EX33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020370.3 → NP_065103.1  G-protein coupled receptor 84

      See identical proteins and their annotated locations for NP_065103.1

      Status: VALIDATED

      Source sequence(s)
      BC020614, BP303386, CD366881
      Consensus CDS
      CCDS8878.1
      UniProtKB/Swiss-Prot
      B6V9G7, Q9NQS5
      UniProtKB/TrEMBL
      A8K2X9
      Related
      ENSP00000267015.3, ENST00000267015.4
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      54350698..54364486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429017.1 → XP_047284973.1  G-protein coupled receptor 84 isoform X2

      UniProtKB/TrEMBL
      A8K2X9

    2. XM_011538495.3 → XP_011536797.1  G-protein coupled receptor 84 isoform X1

      See identical proteins and their annotated locations for XP_011536797.1

      UniProtKB/Swiss-Prot
      B6V9G7, Q9NQS5
      UniProtKB/TrEMBL
      A8K2X9
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      54317281..54331118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372309.1 → XP_054228284.1  G-protein coupled receptor 84 isoform X2

      UniProtKB/TrEMBL
      A8K2X9

    2. XM_054372308.1 → XP_054228283.1  G-protein coupled receptor 84 isoform X1

      UniProtKB/Swiss-Prot
      B6V9G7, Q9NQS5
      UniProtKB/TrEMBL
      A8K2X9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQS5.1 GenPept UniProtKB/Swiss-Prot:Q9NQS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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