KIF26B kinesin family member 26B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF26Bprovided by HGNC
Official Full Name: kinesin family member 26Bprovided by HGNC
Primary source: HGNC:HGNC:25484
See related: Ensembl:ENSG00000162849 MIM:614026; AllianceGenome:HGNC:25484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
Expression: Broad expression in placenta (RPKM 1.6), endometrium (RPKM 0.9) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q44

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (245154985..245709432)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (244572450..245130184)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (245318287..245872734)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer.
Title: KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer.
Noncoding RNAs-based high KIF26B expression correlates with poor prognosis and tumor immune infiltration in colon cancer.
Title: Noncoding RNAs-based high KIF26B expression correlates with poor prognosis and tumor immune infiltration in colon cancer.
Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
Title: Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification.
Title: The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification.
KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.
Title: KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.
ELK1-induced up-regulation of KIF26B promotes cell cycle progression in breast cancer.
Title: ELK1-induced up-regulation of KIF26B promotes cell cycle progression in breast cancer.
Our results did prove a statistical association of both rs2228557 and rs12407427 genotypes (TT and CT + CC) and allele (T) with KTCN susceptibility in Iranian population.
Title: Association of KIF26B and COL4A4 gene polymorphisms with the risk of keratoconus in a sample of Iranian population.
KIF26B may play a critical role in the brain development and, when mutated, cause pontocerebellar hypoplasia with arthrogryposis.
Title: De novo variant in KIF26B is associated with pontocerebellar hypoplasia with infantile spinal muscular atrophy.
KIF26B promoted the development and progression of breast cancer and might act as a potential therapeutic target for treating breast cancer.
Title: KIF26B promotes cell proliferation and migration through the FGF2/ERK signaling pathway in breast cancer.
Upregulation of KIF26B enhanced proliferation and migration of ovarian cancer cells in vitro
Title: Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV Vif interacts with KIF26B	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S2535 (e-PCR)
- UniSTS:48409

B358WG1 (e-PCR)
- UniSTS:42541

G63478 (e-PCR)
- UniSTS:140590

SHGC-111705 (e-PCR)
- UniSTS:168496

G59332 (e-PCR)
- UniSTS:136498

SHGC-153409 (e-PCR)
- UniSTS:177729

AL034002 (e-PCR)
- UniSTS:93516

AL034011 (e-PCR)
- UniSTS:93525

G34828 (e-PCR)
- UniSTS:23928

D1S423 (e-PCR), detects polymorphism
- UniSTS:42628

AL009620 (e-PCR)
- UniSTS:74128

SHGC-146507 (e-PCR)
- UniSTS:175262

RH123454 (e-PCR)
- UniSTS:135842

A274ZC5 (e-PCR)
- UniSTS:8102

AL033799 (e-PCR)
- UniSTS:93657

AL009638 (e-PCR)
- UniSTS:49895

D1S423 (e-PCR), detects polymorphism
- UniSTS:54000

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in establishment of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud invasion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF26B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_053061.1 RefSeqGene

Range

5001..559448

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_018012.4 → NP_060482.2 kinesin-like protein KIF26B

See identical proteins and their annotated locations for NP_060482.2

Status: REVIEWED

Source sequence(s)

AC104462, AY923834

Consensus CDS

CCDS44342.1

UniProtKB/Swiss-Prot

Q2KJY2, Q6ZQR9, Q6ZUZ0, Q8IUN3, Q8IVR1, Q9NWB4

UniProtKB/TrEMBL

A0A0G2JR66

Related

ENSP00000385545.2, ENST00000407071.7

Conserved Domains (2) summary

smart00129
Location:451 → 798

KISc; Kinesin motor, catalytic domain. ATPase

cd00106
Location:450 → 798

KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

245154985..245709432

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187516.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

46767..407457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017030182.2 → XP_016885671.1 kinesin-like protein KIF26B isoform X1

UniProtKB/TrEMBL

A0A0G2JR66

Conserved Domains (2) summary

smart00129
Location:251 → 598

KISc; Kinesin motor, catalytic domain. ATPase

cd00106
Location:250 → 598

KISc; Kinesin motor domain
XM_017030183.1 → XP_016885672.1 kinesin-like protein KIF26B isoform X2

UniProtKB/TrEMBL

A0A0G2JR66, B7WPD9

Conserved Domains (2) summary

smart00129
Location:70 → 417

KISc; Kinesin motor, catalytic domain. ATPase

cd00106
Location:69 → 417

KISc; Kinesin motor domain