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    ndufab1b NADH:ubiquinone oxidoreductase subunit AB1b [ Danio rerio (zebrafish) ]

    Gene ID: 325712, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ndufab1bprovided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit AB1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4437
    See related
    Ensembl:ENSDARG00000014915 AllianceGenome:ZFIN:ZDB-GENE-030131-4437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ndufab1; wu:fd05g01
    Summary
    Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be part of mitochondrial respiratory chain complex I. Predicted to be active in mitochondrion. Orthologous to human NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ndufab1b in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (35535978..35541378, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (35406470..35411870, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene retinoblastoma binding protein 6 Neighboring gene trinucleotide repeat containing adaptor 6A Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene dynactin 5 Neighboring gene guanine nucleotide binding protein (G protein), gamma 13b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis. Williams CM, et al. J Thromb Haemost, 2011 Dec. PMID 21951302
    2. Molecular cloning and expression pattern of 11 genes involved in lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Zheng JL, et al. Gene, 2013 Nov 15. PMID 23988502
    3. FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science. Ma AC, et al. Hum Gene Ther, 2016 Jun. PMID 26854857, Free PMC Article
    4. GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling. Willaert A, et al. Hum Mol Genet, 2012 Mar 15. PMID 22116938, Free PMC Article
    5. Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. Lee JY, et al. Sci Total Environ, 2021 Jun 1. PMID 33548715

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyl binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH:ubiquinone oxidoreductase subunit AB1b
    Names
    NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1
    NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305569.1 → NP_001292498.1  NADH:ubiquinone oxidoreductase subunit AB1b

      See identical proteins and their annotated locations for NP_001292498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH447216, EH519497, EH556548
      UniProtKB/TrEMBL
      A0A8M1P1B3, F1QCE9
      Related
      ENSDARP00000148152.1, ENSDART00000183075.1
      Conserved Domains (1) summary
      cl09936
      Location:29 → 149
      PP-binding; Phosphopantetheine attachment site

    2. NM_001305570.1 → NP_001292499.1  NADH:ubiquinone oxidoreductase subunit AB1b

      See identical proteins and their annotated locations for NP_001292499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH432779, EH519497, EH556548
      UniProtKB/TrEMBL
      A0A8M1P1B3, F1QCE9
      Related
      ENSDARP00000012558.6, ENSDART00000022147.8
      Conserved Domains (1) summary
      cl09936
      Location:29 → 149
      PP-binding; Phosphopantetheine attachment site

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      35535978..35541378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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