nampt2 nicotinamide phosphoribosyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nampt2provided by ZNC
Official Full Name: nicotinamide phosphoribosyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2931
See related: Ensembl:ENSDARG00000027183 AllianceGenome:ZFIN:ZDB-GENE-030131-2931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: namptb; zgc:55764; im:7051384; wu:fc21g12; wu:fc27h03; wu:fd15d03
Summary: Predicted to enable nicotinamide phosphoribosyltransferase activity. Predicted to be involved in NAD biosynthetic process. Predicted to act upstream of or within pyridine nucleotide biosynthetic process and rhythmic process. Predicted to be located in cytoplasm; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (19729766..19775182, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (19567424..19612840, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI722954 (e-PCR)
- UniSTS:205977

fd15d03.x1 (e-PCR)
- UniSTS:204196

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nicotinamide phosphoribosyltransferase 2

Names: nicotinamide phosphoribosyltransferase b; pre-B-cell colony-enhancing factor

NP_997833.2

EC 2.4.2.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212668.2 → NP_997833.2 nicotinamide phosphoribosyltransferase 2

Status: VALIDATED

Source sequence(s)

BX324130, CU914143, EH551317, EH572450

UniProtKB/TrEMBL

A0A8M1PFF2, F1RDZ8

Related

ENSDARP00000028505.9, ENSDART00000037894.10

Conserved Domains (2) summary

PRK09198
Location:8 → 467

PRK09198; putative nicotinate phosphoribosyltransferase; Provisional

cd01569
Location:10 → 417

PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...