nup107 nucleoporin 107 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nup107provided by ZNC
Official Full Name: nucleoporin 107provided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-245
See related: Ensembl:ENSDARG00000016010 AllianceGenome:ZFIN:ZDB-GENE-041210-245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:152723; si:dkey-27k7.3
Summary: Predicted to be a structural constituent of nuclear pore. Acts upstream of or within mRNA export from nucleus and nuclear pore complex assembly. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore outer ring. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Orthologous to human NUP107 (nucleoporin 107). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (22730795..22749553, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (23009820..23028578, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that zygotic nup107 mutant embryos show tissue-specific defects with impaired nuclear export of mRNAs.
Title: Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear pore complex protein Nup107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030167.1 → NP_001025338.1 nuclear pore complex protein Nup107

Status: PROVISIONAL

Source sequence(s)

BX897665

UniProtKB/TrEMBL

A0A8M1N7A2, Q5RGI2

Related

ENSDARP00000040032.7, ENSDART00000040033.9

Conserved Domains (1) summary

pfam04121
Location:204 → 902

Nup84_Nup100; Nuclear pore protein 84 / 107