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    Ss18l1 SS18, nBAF chromatin remodeling complex subunit like 1 [ Mus musculus (house mouse) ]

    Gene ID: 269397, updated on 12-May-2024

    Summary

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    Official Symbol
    Ss18l1provided by MGI
    Official Full Name
    SS18, nBAF chromatin remodeling complex subunit like 1provided by MGI
    Primary source
    MGI:MGI:2444061
    See related
    Ensembl:ENSMUSG00000039086 AllianceGenome:MGI:2444061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CREST; A230053O16Rik
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within dendrite development and positive regulation of dendrite morphogenesis. Located in condensed chromosome, centromeric region. Part of nBAF complex. Is expressed in brain; primary oocyte; spermatocyte; and testis. Orthologous to human SS18L1 (SS18L1 subunit of BAF chromatin remodeling complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 17.2), whole brain E14.5 (RPKM 15.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ss18l1 in Genome Data Viewer
    Location:
    2 H4; 2 102.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179684276..179711994)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180042483..180070201)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene LSM family member 14B Neighboring gene proteasome subunit alpha 7 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene mitochondrial ribosome associated GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene histamine receptor H3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice. Cheng C, et al. Transl Neurodegener, 2019. PMID 30976389, Free PMC Article
    2. CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity. Alaghband Y, et al. J Neurosci, 2018 Oct 31. PMID 30228227, Free PMC Article
    3. Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. de Bruijn DR, et al. Hum Mol Genet, 2006 Oct 1. PMID 16926188
    4. Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter. Thamotharan S, et al. Am J Physiol Endocrinol Metab, 2013 Mar 15. PMID 23321477, Free PMC Article
    5. A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos. Chang CC, et al. Dev Biol, 2005 Feb 15. PMID 15680357

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CREST in the nucleus accumbens core is required for cocaine-induced conditioned place preference, synaptic plasticity and cocaine-seeking behavior.
      Title: CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity.
    2. Data suggest that co-activation of CREST and CBP (CREB-binding protein) enhances signaling between p-Creb/AP-1 and p-HIF-1/HRE resulting in up-regulation of Glut3 (glucose transporter type 3); here, stimulus was cell hypoxia.
      Title: Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of nBAF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-responsive transactivator
    Names
    SS18-like protein 1
    synovial sarcoma translocation gene on chromosome 18-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178750.5 → NP_848865.4  calcium-responsive transactivator

      See identical proteins and their annotated locations for NP_848865.4

      Status: VALIDATED

      Source sequence(s)
      AK133944, BC054730, BY274705
      Consensus CDS
      CCDS17167.1
      UniProtKB/Swiss-Prot
      Q6A014, Q7TQF3, Q8BW22, Q8BYQ7
      Related
      ENSMUSP00000041288.9, ENSMUST00000041126.9
      Conserved Domains (1) summary
      pfam05030
      Location:14 → 73
      SSXT; SSXT protein (N-terminal region)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179684276..179711994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500632.2 → XP_006500695.1  calcium-responsive transactivator isoform X2

    2. XM_006500631.5 → XP_006500694.1  calcium-responsive transactivator isoform X1

      Conserved Domains (1) summary
      pfam05030
      Location:1 → 50
      SSXT; SSXT protein (N-terminal region)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BW22.1 GenPept UniProtKB/Swiss-Prot:Q8BW22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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