Sp9 trans-acting transcription factor 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sp9provided by MGI
Official Full Name: trans-acting transcription factor 9provided by MGI
Primary source: MGI:MGI:3574660
See related: Ensembl:ENSMUSG00000068859 AllianceGenome:MGI:3574660
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic limb morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including embryo ectoderm and limb epithelium. Orthologous to human SP9 (Sp9 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 7.9), frontal lobe adult (RPKM 7.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 43.52 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (73094809..73106115)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (73271926..73275771)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
Title: Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
our results demonstrate that Sp8 and Sp9 have crucial roles in regulating olfactory bulb interneuron development
Title: Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
Title: SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth.
Title: Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor Sp9

Names: buttonhead-like zinc finger transcription factor Sp9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005343.3 → NP_001005343.1 transcription factor Sp9

See identical proteins and their annotated locations for NP_001005343.1

Status: VALIDATED

Source sequence(s)

AL954713

Consensus CDS

CCDS16126.1

UniProtKB/Swiss-Prot

Q5QR89, Q64HY3

Related

ENSMUSP00000088322.6, ENSMUST00000090813.6

Conserved Domains (4) summary

sd00017
Location:337 → 356

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:392 → 414

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:378 → 401

zf-H2C2_2; Zinc-finger double domain

cd22549
Location:19 → 333

SP9_N; N-terminal domain of transcription factor Specificity Protein (SP) 9 and similar proteins
NM_001409583.1 → NP_001396512.1 transcription factor Sp9

Status: VALIDATED

Source sequence(s)

AL954713

UniProtKB/Swiss-Prot

Q5QR89, Q64HY3