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    Tceal3 transcription elongation factor A (SII)-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 594844, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tceal3provided by MGI
    Official Full Name
    transcription elongation factor A (SII)-like 3provided by MGI
    Primary source
    MGI:MGI:1913354
    See related
    Ensembl:ENSMUSG00000044550 AllianceGenome:MGI:1913354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1100001D19Rik
    Summary
    Predicted to enable WW domain binding activity. Predicted to be active in nucleus. Is expressed in several structures, including diaphragm; limb segment; nervous system; retina layer; and skeletal musculature. Orthologous to human TCEAL3 (transcription elongation factor A like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 55.6), cortex adult (RPKM 42.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tceal3 in Genome Data Viewer
    Location:
    X F1; X 59.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135491586..135569127)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136590837..136668378)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene presenilin associated, rhomboid-like pseudogene Neighboring gene nuclear encoded tRNA alanine 1 (anticodon TGC) Neighboring gene acyl-protein thioesterase 1 pseudogene Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury. Lukomska A, et al. Neurosci Lett, 2021 Nov 20. PMID 34560191, Free PMC Article
    2. Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Navas-Pérez E, et al. Genome Biol, 2020 Oct 26. PMID 33100228, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury.
      Title: Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein-like 3
    Names
    TCEA-like protein 3
    transcription elongation factor S-II protein-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029978.3 → NP_001025149.2  transcription elongation factor A protein-like 3

      See identical proteins and their annotated locations for NP_001025149.2

      Status: VALIDATED

      Source sequence(s)
      AK017585, BY124512, CB522987
      Consensus CDS
      CCDS30420.1
      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Related
      ENSMUSP00000059401.5, ENSMUST00000060904.11
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    2. NM_001359277.1 → NP_001346206.1  transcription elongation factor A protein-like 3

      Status: VALIDATED

      Source sequence(s)
      AK158996, BY124512, CB522987
      Consensus CDS
      CCDS30420.1
      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Related
      ENSMUSP00000108724.2, ENSMUST00000113100.2
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    3. NM_001359278.1 → NP_001346207.1  transcription elongation factor A protein-like 3

      Status: VALIDATED

      Source sequence(s)
      AL671887, CB522987
      Consensus CDS
      CCDS30420.1
      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Related
      ENSMUSP00000117087.2, ENSMUST00000128040.2
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    4. NM_001359279.1 → NP_001346208.1  transcription elongation factor A protein-like 3

      Status: VALIDATED

      Source sequence(s)
      AL671887, BY262982, CB522987
      Consensus CDS
      CCDS30420.1
      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135491586..135569127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528586.4 → XP_006528649.1  transcription elongation factor A protein-like 3 isoform X1

      See identical proteins and their annotated locations for XP_006528649.1

      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    2. XM_030251459.2 → XP_030107319.1  transcription elongation factor A protein-like 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    3. XM_030251460.1 → XP_030107320.1  transcription elongation factor A protein-like 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family

    4. XM_030251461.1 → XP_030107321.1  transcription elongation factor A protein-like 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AEC3, Q8R0A5, Q9CYK5, Q9D1S4
      Conserved Domains (1) summary
      pfam04538
      Location:80 → 170
      BEX; Brain expressed X-linked like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0A5.2 GenPept UniProtKB/Swiss-Prot:Q8R0A5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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