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    Cdh26 cadherin-like 26 [ Mus musculus (house mouse) ]

    Gene ID: 381409, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cdh26provided by MGI
    Official Full Name
    cadherin-like 26provided by MGI
    Primary source
    MGI:MGI:2685856
    See related
    Ensembl:ENSMUSG00000039155 AllianceGenome:MGI:2685856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1010
    Summary
    Predicted to enable several functions, including alpha-catenin binding activity; beta-catenin binding activity; and cell adhesion molecule binding activity. Predicted to be involved in CD4-positive, alpha-beta T cell activation and cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in microtubule cytoskeleton and plasma membrane. Predicted to be part of catenin complex. Is expressed in brain; gut; male reproductive gland or organ; and retina. Orthologous to human CDH26 (cadherin 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H4; 2 99.94 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (178072263..178129159)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178430515..178487366)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3D Neighboring gene family with sequence similarity 217, member B Neighboring gene predicted gene, 35532 Neighboring gene predicted gene, 54095 Neighboring gene predicted gene, 35582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma. Feng Y, et al. Am J Respir Cell Mol Biol, 2022 Nov. PMID 35930423
    2. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis. Liu T, et al. Laryngoscope, 2023 Jul. PMID 36069256
    3. HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis. Desgrange A, et al. Development, 2017 Dec 15. PMID 29158444
    4. Type II cadherins guide assembly of a direction-selective retinal circuit. Duan X, et al. Cell, 2014 Aug 14. PMID 25126785
    5. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. Lun MP, et al. J Neurosci, 2015 Mar 25. PMID 25810521, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
      Title: Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
    2. Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.
      Title: Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC56946

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-like protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291189.2 → NP_001278118.1  cadherin-like protein 26 isoform b precursor

      See identical proteins and their annotated locations for NP_001278118.1

      Status: VALIDATED

      Source sequence(s)
      AL772217, AL773557, AL935120
      Consensus CDS
      CCDS71211.1
      UniProtKB/TrEMBL
      Q3V1P3
      Related
      ENSMUSP00000104540.3, ENSMUST00000108912.9
      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain

    2. NM_198656.3 → NP_941058.1  cadherin-like protein 26 isoform a precursor

      See identical proteins and their annotated locations for NP_941058.1

      Status: VALIDATED

      Source sequence(s)
      AL772217, AL773557, AL935120
      Consensus CDS
      CCDS17162.1
      UniProtKB/Swiss-Prot
      P59862
      Related
      ENSMUSP00000048829.9, ENSMUST00000042092.9
      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      178072263..178129159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500670.3 → XP_006500733.1  cadherin-like protein 26 isoform X1

      Conserved Domains (1) summary
      cd11304
      Location:43 → 145
      Cadherin_repeat; Cadherin tandem repeat domain

    2. XM_011239950.1 → XP_011238252.1  cadherin-like protein 26 isoform X2

      Conserved Domains (1) summary
      cd11304
      Location:147 → 228
      Cadherin_repeat; Cadherin tandem repeat domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59862.1 GenPept UniProtKB/Swiss-Prot:P59862

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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