Casz1 castor zinc finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casz1provided by MGI
Official Full Name: castor zinc finger 1provided by MGI
Primary source: MGI:MGI:1196251
See related: Ensembl:ENSMUSG00000028977 AllianceGenome:MGI:1196251
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cst; D4Ertd432e; 2410019P08Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and retina morphogenesis in camera-type eye. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Used to study chromosome 1p36 deletion syndrome. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in small intestine adult (RPKM 25.0), duodenum adult (RPKM 22.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.87 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148888823..149039350)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148804366..148954893)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.
Title: A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.
these data identify Casz1 as a new Th plasticity regulator having important clinical implications for autoimmune inflammation and mucosal immunity.
Title: Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity.
these data support a model in which Casz1 cooperates with polycomb to control rod genome organization, in part by silencing lamin A/C.
Title: Casz1 controls higher-order nuclear organization in rod photoreceptors.
Study shows that Casz1 lies downstream of Prrxl1 in the differentiation pathway of a large subset of dorsal late-born excitatory neurons and provides a framework for further studies of Casz1 in assembly of the dorsal root ganglion-spinal circuit.
Title: Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late-born excitatory interneurons.
Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)
Title: Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.
these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields.
Title: Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.
Casz1 is expressed from mid/late stages in retinal progenitor cells.
Title: A conserved regulatory logic controls temporal identity in mouse neural progenitors.
Abnormal expression of cardiac morphogenesis and contraction genes induced by loss of Casz1 contributes to the heart defect.
Title: Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.
report the expression pattern of a murine Castor related gene (Cst) during embryogenesis [cst]
Title: Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124782 (e-PCR)
- UniSTS:161604

BB450868 (e-PCR)
- UniSTS:207724

D4Mit129 (e-PCR), detects polymorphism
- UniSTS:129903

AV096627 (e-PCR)
- UniSTS:164269

D4Ertd432e (e-PCR), detects polymorphism
- UniSTS:167395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amacrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of retinal cone cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal bipolar neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinal rod cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinal rod cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein castor homolog 1

Names: castor homolog 1, zinc finger; castor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159344.1 → NP_001152816.1 zinc finger protein castor homolog 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL607145, AL611967

Consensus CDS

CCDS51379.1

UniProtKB/Swiss-Prot

A2A8A1, Q69Z25, Q9CWL2

UniProtKB/TrEMBL

B1AS46

Related

ENSMUSP00000112978.2, ENSMUST00000122222.8

Conserved Domains (1) summary

PHA03247
Location:799 → 1158

PHA03247; large tegument protein UL36; Provisional
NM_027195.2 → NP_081471.2 zinc finger protein castor homolog 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC075673, BI738136

Consensus CDS

CCDS38973.1

UniProtKB/Swiss-Prot

Q9CWL2

Related

ENSMUSP00000092035.4, ENSMUST00000094464.10

Conserved Domains (1) summary

PHA03247
Location:799 → 1158

PHA03247; large tegument protein UL36; Provisional

RNA

NR_161310.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL607145, BC040081

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

148888823..149039350

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539158.2 → XP_006539221.1 zinc finger protein castor homolog 1 isoform X2

See identical proteins and their annotated locations for XP_006539221.1

UniProtKB/Swiss-Prot

A2A8A1, Q69Z25, Q9CWL2

Conserved Domains (1) summary

PHA03247
Location:799 → 1158

PHA03247; large tegument protein UL36; Provisional
XM_006539159.5 → XP_006539222.1 zinc finger protein castor homolog 1 isoform X2

See identical proteins and their annotated locations for XP_006539222.1

UniProtKB/Swiss-Prot

A2A8A1, Q69Z25, Q9CWL2

Conserved Domains (1) summary

PHA03247
Location:799 → 1158

PHA03247; large tegument protein UL36; Provisional
XM_006539157.5 → XP_006539220.1 zinc finger protein castor homolog 1 isoform X1

UniProtKB/Swiss-Prot

A2A8A1, Q69Z25, Q9CWL2

Conserved Domains (1) summary

PHA03247
Location:823 → 1182

PHA03247; large tegument protein UL36; Provisional
XM_006539160.5 → XP_006539223.1 zinc finger protein castor homolog 1 isoform X3

UniProtKB/Swiss-Prot

A2A8A1, Q69Z25, Q9CWL2

Conserved Domains (1) summary

PHA03247
Location:823 → 1182

PHA03247; large tegument protein UL36; Provisional