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    ZG16B zymogen granule protein 16B [ Homo sapiens (human) ]

    Gene ID: 124220, updated on 3-May-2024

    Summary

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    Official Symbol
    ZG16Bprovided by HGNC
    Official Full Name
    zymogen granule protein 16Bprovided by HGNC
    Primary source
    HGNC:HGNC:30456
    See related
    Ensembl:ENSG00000162078 MIM:620477; AllianceGenome:HGNC:30456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EECP; PAUF; JCLN2; HRPE773; PRO1567
    Summary
    Predicted to enable carbohydrate binding activity. Involved in retina homeostasis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward salivary gland (RPKM 15006.7) See more
    Orthologs
    all
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    Genomic context

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    See ZG16B in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2830303..2832276)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2850876..2852849)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2880304..2882277)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870033-2870534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870535-2871034 Neighboring gene serine protease 21 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 4 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:2885634-2886833 Neighboring gene uncharacterized LOC124903628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2892359-2893048 Neighboring gene serine protease 30, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2902227-2902726 Neighboring gene serine protease 22 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2907556-2908156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908157-2908757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals. Ghosh S, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216558, Free PMC Article
    2. Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor. Yoo W, et al. Exp Mol Med, 2021 Mar. PMID 33731895, Free PMC Article
    3. PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/β-catenin pathway. Escudero-Paniagua B, et al. Carcinogenesis, 2020 Apr 22. PMID 31095674
    4. Pancreatic adenocarcinoma up-regulated factor has oncogenic functions in oral squamous cell carcinoma. Sasahira T, et al. Histopathology, 2017 Mar. PMID 27706833
    5. Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer. Song J, et al. Oncotarget, 2016 Aug 9. PMID 27322081, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.
      Title: Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.
    2. PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway.
      Title: PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway.
    3. Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor.
      Title: Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor.
    4. PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/beta-catenin pathway.
      Title: PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/β-catenin pathway.
    5. we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells
      Title: Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer.
    6. Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF.
      Title: DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer.
    7. Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma
      Title: Pancreatic adenocarcinoma up-regulated factor has oncogenic functions in oral squamous cell carcinoma.
    8. High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer.
      Title: Silencing pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer cells to gemcitabine.
    9. PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4
      Title: Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4.
    10. constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection
      Title: Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pancreatic adenocarcinoma up-regulated factor; zymogen granule protein 16 homolog B
    Names
    endocrine and exocrine protein
    jacalin-like lectin domain containing 2
    pancreatic adenocarcinoma upregulated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145252.3 → NP_660295.3  pancreatic adenocarcinoma up-regulated factor precursor

      Status: VALIDATED

      Source sequence(s)
      AC005361
      Consensus CDS
      CCDS10479.3
      UniProtKB/Swiss-Prot
      A6NIY1, B2R4F6, C3PTT6, Q6UW28, Q96DA0
      UniProtKB/TrEMBL
      A0A0C4DGN4, A0A0U1RQZ6
      Related
      ENSP00000371715.4, ENST00000382280.8
      Conserved Domains (1) summary
      cd09611
      Location:21 → 148
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2830303..2832276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171812.1 Reference GRCh38.p14 PATCHES

      Range
      5439..11741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331877.1 → XP_054187852.1  zymogen granule protein 16 homolog B isoform X1

      UniProtKB/TrEMBL
      G8H6I3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2850876..2852849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96DA0.4 GenPept UniProtKB/Swiss-Prot:Q96DA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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