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    Zfp300 zinc finger protein 300 [ Mus musculus (house mouse) ]

    Gene ID: 245368, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zfp300provided by MGI
    Official Full Name
    zinc finger protein 300provided by MGI
    Primary source
    MGI:MGI:3045326
    See related
    Ensembl:ENSMUSG00000031079 AllianceGenome:MGI:3045326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D930016N04Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp300 in Genome Data Viewer
    Location:
    X A1.3; X 16.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20944447..20955934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (21078208..21089698, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 182 Neighboring gene STARR-seq mESC enhancer starr_46890 Neighboring gene STARR-seq mESC enhancer starr_46891 Neighboring gene sperm acrosome associated 5 Neighboring gene SSX member A1 Neighboring gene STARR-seq mESC enhancer starr_46892 Neighboring gene Na K-ATPase beta-3 subunit pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 300
    Names
    Novel KRAB box containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358840.1 → NP_001345769.1  zinc finger protein 300 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671853
      Conserved Domains (3) summary
      smart00349
      Location:8 → 63
      KRAB; krueppel associated box
      COG5048
      Location:249 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:386 → 406
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_183185.3 → NP_899008.2  zinc finger protein 300 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK053018, AL671853
      Consensus CDS
      CCDS30050.1
      UniProtKB/TrEMBL
      A2AE21
      Related
      ENSMUSP00000046514.7, ENSMUST00000040667.13
      Conserved Domains (6) summary
      smart00349
      Location:7 → 62
      KRAB; krueppel associated box
      COG5048
      Location:248 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:385 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:554 → 576
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:454 → 477
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      20944447..20955934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527628.4 → XP_006527691.1  zinc finger protein 300 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:8 → 63
      KRAB; krueppel associated box
      COG5048
      Location:248 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:385 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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