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    Zfp709 zinc finger protein 709 [ Mus musculus (house mouse) ]

    Gene ID: 236193, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp709provided by MGI
    Official Full Name
    zinc finger protein 709provided by MGI
    Primary source
    MGI:MGI:2384299
    See related
    Ensembl:ENSMUSG00000056019 AllianceGenome:MGI:2384299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GIOT-4; HIT-40
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to heat; cellular response to lipopolysaccharide; and negative regulation of transcription by RNA polymerase II. Predicted to be located in plasma membrane. Is expressed in bladder; ureter; and urethra of female. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 1.1), placenta adult (RPKM 1.0) and 25 other tissues See more
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    Genomic context

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    Location:
    8 B3.3; 8 34.57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72635912..72646409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71882068..71892565)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:74351108-74351408 Neighboring gene predicted gene, 57790 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74352588-74352888 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74358279-74358580 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74358941-74359242 Neighboring gene STARR-positive B cell enhancer ABC_E5017 Neighboring gene STARR-positive B cell enhancer ABC_E10510 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74367100-74367401 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74368145-74368446 Neighboring gene STARR-positive B cell enhancer ABC_E6658 Neighboring gene STARR-positive B cell enhancer ABC_E8244 Neighboring gene STARR-positive B cell enhancer ABC_E6659 Neighboring gene STARR-positive B cell enhancer ABC_E6660 Neighboring gene STARR-positive B cell enhancer ABC_E6661 Neighboring gene STARR-positive B cell enhancer ABC_E9730 Neighboring gene predicted gene 5373 Neighboring gene vomeronasal 2, receptor, pseudogene 91 Neighboring gene STARR-seq mESC enhancer starr_21833 Neighboring gene STARR-positive B cell enhancer ABC_E10511 Neighboring gene cyclin B2, pseudogene Neighboring gene zinc finger protein 882 Neighboring gene zinc finger protein 617

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC28841

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 709

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145624.4 → NP_663599.3  zinc finger protein 709

      See identical proteins and their annotated locations for NP_663599.3

      Status: VALIDATED

      Source sequence(s)
      AK031294, BM941264, DV656777, DV662339
      Consensus CDS
      CCDS80897.1
      UniProtKB/TrEMBL
      Q8VC29
      Related
      ENSMUSP00000140285.2, ENSMUST00000188685.7
      Conserved Domains (5) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      COG5048
      Location:251 → 693
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:591 → 611
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:436 → 459
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72635912..72646409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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