Mrgprx1 MAS-related GPR, member X1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrgprx1provided by MGI
Official Full Name: MAS-related GPR, member X1provided by MGI
Primary source: MGI:MGI:3033139
See related: Ensembl:ENSMUSG00000070552 AllianceGenome:MGI:3033139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MrgC11; Mrgprc11
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human MRGPRX1 (MAS related GPR family member X1); MRGPRX3 (MAS related GPR family member X3); and MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 B4; 7 31.09 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (47670719..47677345, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (48020971..48027597, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MrgprC11(+) sensory neurons mediate glabrous skin itch.
Title: MrgprC11(+) sensory neurons mediate glabrous skin itch.
Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.
Title: Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.
Our findings established a novel function for Mrgprc11 in the gut nociceptive innervation
Title: Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?
SLIGRL-amide inhibits influenza A virus infection independently of MRGPRC11 and independently of capsaicin-sensitive, neuropeptide-releasing sensory nerves.
Title: Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.
Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation.
Title: Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.
Cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice.
Title: Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.
Results suggest that activation of MrgC11 may inhibit high-voltage-activated calcium current in mouse dorsal root ganglion neurons through a voltage-independent mechanism that involves activation of the phospholipase C, but not Galphai or Galphas, pathway
Title: The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.
analysis of the functional interactions between MRGPR-X1 and TRPV1
Title: Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
although both Mrgpr and PAR2 are SLIGRL-responsive G protein-coupled receptors present in dorsal root ganglia, each plays a specific role in mediating itch and pain.
Title: The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.
Mouse bone marrow-derived mast cells express the MrgC11 receptor agonist, RF-amide precursor gene proneuropeptide FF.
Title: Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemosensory behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member X1

Names: MAS-related GPR, member C11; mas-related G-protein coupled receptor member C11; sensory neuron-specific G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207540.3 → NP_997423.1 mas-related G-protein coupled receptor member X1

See identical proteins and their annotated locations for NP_997423.1

Status: PROVISIONAL

Source sequence(s)

AY152435

Consensus CDS

CCDS21299.1

UniProtKB/Swiss-Prot

Q8CIP3

UniProtKB/TrEMBL

B2RWR5

Related

ENSMUSP00000091954.2, ENSMUST00000094390.3

Conserved Domains (1) summary

pfam00001
Location:43 → 274

7tm_1; 7 transmembrane receptor (rhodopsin family)