Tinag tubulointerstitial nephritis antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tinagprovided by MGI
Official Full Name: tubulointerstitial nephritis antigenprovided by MGI
Primary source: MGI:MGI:1349477
See related: Ensembl:ENSMUSG00000032357 AllianceGenome:MGI:1349477
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIN-ag
Summary: Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Located in collagen-containing extracellular matrix. Is expressed in lung; metanephros; and pancreas. Orthologous to human TINAG (tubulointerstitial nephritis antigen). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 24.4), large intestine adult (RPKM 3.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.67 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (76858980..76953084, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (76951698..77045802, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, our results underscore the significance of TINAG in Hepatocellular carcinoma (HCC)progression and prognosis, and TINAG might be a novel candidate oncogene in HCC. These results propose that targeting TINAG might offer future clinical utility in HCC.
Title: Activation of PI3K/AKT is involved in TINAG-mediated promotion of proliferation, invasion and migration of hepatocellular carcinoma.
Altered interactions between C/EBP-beta and TINag play a critical role in the pathophysiology of renal injury after obstruction.
Title: C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tubulointerstitial nephritis antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012033.3 → NP_036163.3 tubulointerstitial nephritis antigen precursor

See identical proteins and their annotated locations for NP_036163.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript.

Source sequence(s)

AC140981

Consensus CDS

CCDS23351.1

UniProtKB/TrEMBL

Q91XG7, Q9WUR0

Related

ENSMUSP00000034911.6, ENSMUST00000034911.7

Conserved Domains (3) summary

cd02620
Location:217 → 465

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam01033
Location:60 → 103

Somatomedin_B; Somatomedin B domain

cl17735
Location:119 → 166

VWC; von Willebrand factor type C domain

RNA

NR_136923.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the most 5' translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC140981, AK008374

Related

ENSMUST00000184897.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

76858980..76953084 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511201.4 → XP_006511264.1 tubulointerstitial nephritis antigen isoform X1

UniProtKB/TrEMBL

Q91XG7

Conserved Domains (2) summary

cd02620
Location:167 → 415

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam01033
Location:60 → 103

Somatomedin_B; Somatomedin B domain
XM_006511202.4 → XP_006511265.1 tubulointerstitial nephritis antigen isoform X2

Conserved Domains (1) summary

cd02620
Location:51 → 299

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...