Pcdhb6 protocadherin beta 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdhb6provided by MGI
Official Full Name: protocadherin beta 6provided by MGI
Primary source: MGI:MGI:2136740
See related: Ensembl:ENSMUSG00000051678 AllianceGenome:MGI:2136740
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PcdhbF; Pcdhb5B
Summary: Enables calcium ion binding activity and identical protein binding activity. Involved in cell-cell recognition and homophilic cell adhesion via plasma membrane adhesion molecules. Is integral component of plasma membrane. Is expressed in brain; liver; and metanephros. Orthologous to human PCDHB5 (protocadherin beta 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 18 B3; 18 19.47 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (37466913..37470491)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (37333860..37337438)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protocadherin beta-6

Names: PCDH-beta-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053131.2 → NP_444361.1 protocadherin beta-6 precursor

See identical proteins and their annotated locations for NP_444361.1

Status: VALIDATED

Source sequence(s)

AC020974

Consensus CDS

CCDS29174.1

UniProtKB/Swiss-Prot

Q91XZ4

UniProtKB/TrEMBL

B2RWV0

Related

ENSMUSP00000058592.3, ENSMUST00000061717.4

Conserved Domains (3) summary

cd11304
Location:247 → 342

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:31 → 112

Cadherin_2; Cadherin-like

pfam16492
Location:686 → 767

Cadherin_C_2; Cadherin cytoplasmic C-terminal