P2RY8 P2Y receptor family member 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: P2RY8provided by HGNC
Official Full Name: P2Y receptor family member 8provided by HGNC
Primary source: HGNC:HGNC:15524
See related: Ensembl:ENSG00000182162 Ensembl:ENSG00000292333 MIM:300525; AllianceGenome:HGNC:15524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P2Y8
Summary: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 13.9), spleen (RPKM 8.9) and 14 other tissues See more
Orthologs: all
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Genomic context

Location:: X;Y

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (1462581..1537185, complement)
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	Y	NC_000024.10 (1462581..1537185, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (1304499..1339638, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	Y	NC_060948.1 (1325951..1401516, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (1581474..1656078, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	Y	NC_000024.9 (1531474..1606078, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Chromosome Y - NC_000024.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
Title: P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
[Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
Title: [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
S-Geranylgeranyl-L-glutathione(GGG) is identified as an intercellular signalling molecule that is involved in organizing and controlling germinal-centre responses; as the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, GGG might have organizing and growth-regulatory roles in multiple human tissues
Title: S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.
P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia.
Title: Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia.
P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner.
Title: The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.
P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone.
Title: Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL.
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
Title: Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement.
Title: Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.
SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma
Title: Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.
P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia
Title: Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXYS140 (e-PCR)
- UniSTS:99589

L77270 (e-PCR)
- UniSTS:5193

DXYS139 (e-PCR)
- UniSTS:147800

GDB:312946 (e-PCR)
- UniSTS:41833

DXYS141 (e-PCR)
- UniSTS:52721

SHGC-64134 (e-PCR)
- UniSTS:167669

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: P2Y purinoceptor 8

Names: G-protein coupled purinergic receptor P2Y8; purinergic receptor P2Y, G-protein coupled, 8; purinergic receptor P2Y8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013252.1 RefSeqGene

Range

4960..79564

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001424186.1 → NP_001411115.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_001424187.1 → NP_001411116.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_001424188.1 → NP_001411117.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_001424189.1 → NP_001411118.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_001424190.1 → NP_001411119.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_001424191.1 → NP_001411120.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_001424192.1 → NP_001411121.1 P2Y purinoceptor 8

Status: REVIEWED

Source sequence(s)

AL683870

UniProtKB/Swiss-Prot

Q86VZ1
NM_178129.5 → NP_835230.1 P2Y purinoceptor 8

See identical proteins and their annotated locations for NP_835230.1

Status: REVIEWED

Source sequence(s)

AI476104, AK092956, AL683870, AL833184, BC043610, BE245848

Consensus CDS

CCDS14115.1

UniProtKB/Swiss-Prot

Q86VZ1

Related

ENSP00000370697.4, ENSP00000518611.1, ENST00000381297.10, ENST00000711216.1

Conserved Domains (1) summary

cd15368
Location:24 → 304

7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

1462581..1537185 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005274429.4 → XP_005274486.1 P2Y purinoceptor 8 isoform X1

See identical proteins and their annotated locations for XP_005274486.1

UniProtKB/Swiss-Prot

Q86VZ1

Conserved Domains (1) summary

cd15368
Location:24 → 304

7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000024.10 Reference GRCh38.p14 Primary Assembly

Range

1462581..1537185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005274778.4 → XP_005274835.1 P2Y purinoceptor 8 isoform X1

See identical proteins and their annotated locations for XP_005274835.1

UniProtKB/Swiss-Prot

Q86VZ1

Conserved Domains (1) summary

cd15368
Location:24 → 304

7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors