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    PRR13 proline rich 13 [ Homo sapiens (human) ]

    Gene ID: 54458, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PRR13provided by HGNC
    Official Full Name
    proline rich 13provided by HGNC
    Primary source
    HGNC:HGNC:24528
    See related
    Ensembl:ENSG00000205352 MIM:610459; AllianceGenome:HGNC:24528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TXR1
    Summary
    Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine (RPKM 163.5), duodenum (RPKM 160.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR13 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53441734..53446638)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53407777..53412682)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53835518..53840422)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4509 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:53774734-53775492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6420 Neighboring gene Sp1 transcription factor Neighboring gene CRISPRi-validated cis-regulatory element chr12.1897 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53834490-53835255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4513 Neighboring gene poly(rC) binding protein 2 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53876139-53876652 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4514 Neighboring gene Sharpr-MPRA regulatory region 1043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6423 Neighboring gene TARBP2 subunit of RISC loading complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role? Erdi F, et al. Turk Neurosurg, 2018. PMID 28345125
    2. Txr1: an important factor in oxaliplatin resistance in gastric cancer. Bi J, et al. Med Oncol, 2014 Feb. PMID 24362794
    3. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Lih CJ, et al. Genes Dev, 2006 Aug 1. PMID 16847352, Free PMC Article
    4. Tumoral expression of TXR1 and TSP1 predicts overall survival of patients with lung adenocarcinoma treated with first-line docetaxel-gemcitabine regimen. Papadaki C, et al. Clin Cancer Res, 2009 Jun 1. PMID 19435835
    5. Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80), HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in patients with epithelial ovarian cancer who received platinum-taxane first-line therapy. Pontikakis S, et al. Pharmacogenomics J, 2017 Dec. PMID 27779244

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicate that PRR13/THBS1 and TXN expression could be used for the prediction of resistance to treatment of epithelial ovarian cancer patients.
      Title: Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80), HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in patients with epithelial ovarian cancer who received platinum-taxane first-line therapy.
    2. In primary glioblastoma samples there was a high expression of TXR1 in cerebral tissue compared to control tissue.
      Title: New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?
    3. High Txr1 expression is associated with oxaliplatin resistance in gastric cancer.
      Title: Txr1: an important factor in oxaliplatin resistance in gastric cancer.
    4. Low TXR1 mRNA levels were associated with higher response rate (RR), longer median progression-free survival (PFS) and median overall survival (mOS), whereas high TSP1 expression was correlated with higher RR, longer PFS and mOS
      Title: Correlation of BRCA1, TXR1 and TSP1 mRNA expression with treatment outcome to docetaxel-based first-line chemotherapy in patients with advanced/metastatic non-small-cell lung cancer.
    5. Multivariate analysis showed that high TXR1/low TSP1 expression was an independent prognostic factor for decreased median time to tumor progression (TTP) and median overall survival (mOS).
      Title: Tumoral expression of TXR1 and TSP1 predicts overall survival of patients with lung adenocarcinoma treated with first-line docetaxel-gemcitabine regimen.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23818, FLJ58476, DKFZp564J157

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich protein 13
    Names
    taxane-resistance protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005354.3 → NP_001005354.1  proline-rich protein 13 isoform 2

      See identical proteins and their annotated locations for NP_001005354.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment in the 5' coding region compared to variant 2. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK074398, BX640962, CN392914
      Consensus CDS
      CCDS31811.1
      UniProtKB/Swiss-Prot
      Q9NZ81
      Related
      ENSP00000369112.4, ENST00000379786.8

    2. NM_018457.4 → NP_060927.1  proline-rich protein 13 isoform 1

      See identical proteins and their annotated locations for NP_060927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC014257, CN392914
      Consensus CDS
      CCDS44899.1
      UniProtKB/Swiss-Prot
      Q0V8U0, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9, Q9NZ81
      UniProtKB/TrEMBL
      F8VU40
      Related
      ENSP00000412064.2, ENST00000429243.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53441734..53446638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53407777..53412682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005355.1: Suppressed sequence

      Description
      NM_001005355.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZ81.1 GenPept UniProtKB/Swiss-Prot:Q9NZ81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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