Gopc golgi associated PDZ and coiled-coil motif containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gopcprovided by MGI
Official Full Name: golgi associated PDZ and coiled-coil motif containingprovided by MGI
Primary source: MGI:MGI:2149946
See related: Ensembl:ENSMUSG00000019861 AllianceGenome:MGI:2149946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAL; FIG; PIST; GOPC1; 2210402P09Rik
Summary: Enables several functions, including frizzled binding activity; protein C-terminus binding activity; and protein homodimerization activity. Acts upstream of or within spermatid nucleus differentiation. Located in Golgi apparatus; plasma membrane; and synapse. Is expressed in genitourinary system and tongue. Used to study azoospermia. Orthologous to human GOPC (golgi associated PDZ and coiled-coil motif containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 7.3), genital fat pad adult (RPKM 6.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 26.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (52213120..52258220, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (52337024..52382124, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5.
Title: The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5.
The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic beta-cells.
Title: The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]
Title: Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.
PIST protein, mouse plays an important role in regulating the intracellular sorting/ localization of cadherin 23.
Title: PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23.
Transmission electron microscope (TEM) images of the spermatozoa were studied quantitatively to analyze disorganization processes during epididymal passage in Gopc knockout mice.
Title: Factors maintaining normal sperm tail structure during epididymal maturation studied in Gopc-/- mice.
The coiled tail of the round-headed spermatozoa appears during epididymal passage in Gopc-deficient mice.
Title: The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice.
Gopc-deficient spermatids fail to assemble the peri-nuclear structures in round-headed spermatozoa during spermatogenesis.
Title: Failure to assemble the peri-nuclear structures in GOPC deficient spermatids as found in round-headed spermatozoa.
predominantly localized at the trans-Golgi region in round spermatids; male mice in which GOPC has been disrupted are infertile with globozoospermia
Title: Lack of acrosome formation in mice lacking a Golgi protein, GOPC.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI844555 (e-PCR)
- UniSTS:164433

Ewsh (e-PCR), detects polymorphism
- UniSTS:259178

GDB:452619 (e-PCR)
- UniSTS:157393

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of anion channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatid nucleus differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Golgi-associated PDZ and coiled-coil motif-containing protein

Names: CFTR-associated ligand; PDZ domain-containing protein PIST; PDZ protein interacting specifically with TC10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199272.1 → NP_001186201.1 Golgi-associated PDZ and coiled-coil motif-containing protein isoform a

See identical proteins and their annotated locations for NP_001186201.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform a).

Source sequence(s)

AK032613, BC051171, BY016379, CF755307, CJ174667

UniProtKB/Swiss-Prot

Q8BH60, Q8BSV4, Q920R1, Q9ET11

UniProtKB/TrEMBL

K3W4Q9

Related

ENSMUSP00000151773.2, ENSMUST00000217753.2

Conserved Domains (1) summary

cd00992
Location:287 → 369

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_053187.3 → NP_444417.2 Golgi-associated PDZ and coiled-coil motif-containing protein isoform b

See identical proteins and their annotated locations for NP_444417.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.

Source sequence(s)

BC051171, BY016379, CF755307, CJ174667

Consensus CDS

CCDS35898.1

UniProtKB/TrEMBL

K3W4Q9

Related

ENSMUSP00000020008.9, ENSMUST00000020008.10

Conserved Domains (1) summary

cd00992
Location:279 → 361

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...