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    Zup1 zinc finger containing ubiquitin peptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 72580, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Zup1provided by MGI
    Official Full Name
    zinc finger containing ubiquitin peptidase 1provided by MGI
    Primary source
    MGI:MGI:1919830
    See related
    Ensembl:ENSMUSG00000039531 AllianceGenome:MGI:1919830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DUB; Zufsp; 2700019D07Rik
    Summary
    Predicted to enable metal ion binding activity and thiol-dependent deubiquitinase. Predicted to be involved in regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZUP1 (zinc finger containing ubiquitin peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.0), CNS E11.5 (RPKM 3.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B1; 10 18.85 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (33795138..33827316, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (33919142..33951294, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 3A, member 1 Neighboring gene STARR-seq mESC enhancer starr_26256 Neighboring gene STARR-seq mESC enhancer starr_26257 Neighboring gene STARR-seq mESC enhancer starr_26258 Neighboring gene radial spoke head 4 homolog A (Chlamydomonas) Neighboring gene predicted gene, 48018 Neighboring gene STARR-seq mESC enhancer starr_26259 Neighboring gene STARR-seq mESC enhancer starr_26260 Neighboring gene STARR-seq mESC enhancer starr_26261 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA A830082N09 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation.
      Title: MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107205

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger-containing ubiquitin peptidase 1
    Names
    lys-63-specific deubiquitinase ZUFSP
    ubiquitin carboxyl-terminal hydrolase ZUFSP
    zinc finger with UFM1-specific peptidase domain protein
    NP_001346384.1
    NP_001346385.1
    NP_082563.1
    XP_006512931.1
    XP_006512932.1
    XP_006512933.1
    XP_030101163.1
    XP_036011935.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359455.1 → NP_001346384.1  zinc finger-containing ubiquitin peptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK077304, AK077730, AV316666
      Consensus CDS
      CCDS87987.1
      UniProtKB/Swiss-Prot
      Q3T9Z9, Q5FWB1, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Related
      ENSMUSP00000151811.2, ENSMUST00000218055.2
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 550
      Peptidase_C78; Peptidase family C78

    2. NM_001359456.1 → NP_001346385.1  zinc finger-containing ubiquitin peptidase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK052071, AK077304, AV316666
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Related
      ENSMUSP00000151662.2, ENSMUST00000218880.2
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 535
      Peptidase_C78; Peptidase family C78

    3. NM_028287.3 → NP_082563.1  zinc finger-containing ubiquitin peptidase 1 isoform 2

      See identical proteins and their annotated locations for NP_082563.1

      Status: VALIDATED

      Source sequence(s)
      AK046191, AK077304, AK164710
      Consensus CDS
      CCDS23772.1
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Related
      ENSMUSP00000037121.5, ENSMUST00000048222.6
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 550
      Peptidase_C78; Peptidase family C78

    RNA

    1. NR_153113.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK077304, AK077730, AV316666, BC067065
      Related
      ENSMUST00000218275.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      33795138..33827316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156042.1 → XP_036011935.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3T9Z9, Q5FWB1, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 550
      Peptidase_C78; Peptidase family C78

    2. XM_030245303.2 → XP_030101163.1  zinc finger-containing ubiquitin peptidase 1 isoform X2

      Conserved Domains (1) summary
      pfam07910
      Location:140 → 355
      Peptidase_C78; Peptidase family C78

    3. XM_006512868.5 → XP_006512931.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006512931.1

      UniProtKB/Swiss-Prot
      Q3T9Z9, Q5FWB1, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 550
      Peptidase_C78; Peptidase family C78

    4. XM_006512870.5 → XP_006512933.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006512933.1

      UniProtKB/Swiss-Prot
      Q3T9Z9, Q5FWB1, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 550
      Peptidase_C78; Peptidase family C78

    5. XM_006512869.5 → XP_006512932.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006512932.1

      UniProtKB/Swiss-Prot
      Q3T9Z9, Q5FWB1, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
      UniProtKB/TrEMBL
      A0A1W2P7K8
      Conserved Domains (1) summary
      pfam07910
      Location:335 → 550
      Peptidase_C78; Peptidase family C78
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T9Z9.2 GenPept UniProtKB/Swiss-Prot:Q3T9Z9

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