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    MSO1 Mso1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855785, updated on 17-May-2024

    Summary

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    Gene symbol
    MSO1
    Gene description
    Mso1p
    Primary source
    FungiDB:YNR049C
    Locus tag
    YNR049C
    See related
    SGD:S000005332; AllianceGenome:SGD:S000005332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ascospore-type prospore membrane formation; membrane fusion; and vesicle docking involved in exocytosis. Located in several cellular components, including cellular bud membrane; cellular bud tip; and prospore membrane. Part of SNARE complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSO1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (713023..713655, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene putative aminophospholipid translocase regulatory protein Neighboring gene saccharopine dehydrogenase (NADP+, L-glutamate-forming) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions. Weber-Boyvat M, et al. Mol Biol Cell, 2013 Feb. PMID 23197474, Free PMC Article
    2. Characterization of the sec1-1 and sec1-11 mutations. Brummer MH, et al. Yeast, 2001 Dec. PMID 11748729
    3. Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. Jäntti J, et al. J Cell Sci, 2002 Jan 15. PMID 11839791
    4. Mso1 is a novel component of the yeast exocytic SNARE complex. Castillo-Flores A, et al. J Biol Chem, 2005 Oct 7. PMID 16087665
    5. Sec1p and Mso1p C-terminal tails cooperate with the SNAREs and Sec4p in polarized exocytosis. Weber-Boyvat M, et al. Mol Biol Cell, 2011 Jan 15. PMID 21119007, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mso1p membrane interactions are essential for correct subcellular localization of Mso1p-Sec1p complexes and for membrane fusion in Saccharomyces cerevisiae.
      Title: A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions.
    2. Mso1p is in the interface of the exocyst complex, Sec4p, and the SNARE machinery, and reveal a novel layer of molecular conservation in the exocytosis machinery.
      Title: Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast.
    3. results suggest that Mso1 is a component of the exocytic SNARE complex and a possible ortholog of the Munc13/Mint proteins
      Title: Mso1 is a novel component of the yeast exocytic SNARE complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane HDA PubMed 
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mso1p
    NP_014447.3
    • Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      713023..713655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183226.3 → NP_014447.3  TPA: Mso1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014447.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M4, P53604
      UniProtKB/TrEMBL
      A0A8H4F7U0, A6ZSC3, B3LPJ4, B5VR74, C7GLK8, C8ZFS8, G2WLA6, N1NY90
      Conserved Domains (1) summary
      pfam14475
      Location:31 → 70
      Mso1_Sec1_bdg; Sec1-binding region of Mso1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53604.1

    Gene LinkOut

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