Ftsj3 FtsJ RNA 2'-O-methyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ftsj3provided by MGI
Official Full Name: FtsJ RNA 2'-O-methyltransferase 3provided by MGI
Primary source: MGI:MGI:1860295
See related: Ensembl:ENSMUSG00000020706 AllianceGenome:MGI:1860295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epcs3; D11Ertd400e
Summary: Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; gonad; liver; retina; and spleen. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.5), liver E14 (RPKM 19.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.89 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106139964..106146910, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106249138..106256084, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
Title: RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ftsj3 (e-PCR), detects polymorphism
- UniSTS:265254

RH124310 (e-PCR)
- UniSTS:161132

RH126751 (e-PCR)
- UniSTS:208756

AW319508 (e-PCR)
- UniSTS:180352

RH127156 (e-PCR)
- UniSTS:167052

MARC_4113-4114:991938380:3 (e-PCR)
- UniSTS:231072

MARC_4113-4114:996679383:1 (e-PCR)
- UniSTS:231072

AU045295 (e-PCR)
- UniSTS:160177

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA 2'-O-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (guanine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA methylation	ISO Inferred from Sequence Orthology more info
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

Names: 2'-O-ribose RNA methyltransferase SPB1 homolog; FtsJ RNA methyltransferase homolog 3; FtsJ homolog 3; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3; pre-rRNA processing protein FTSJ3; protein ftsJ homolog 3; putative rRNA methyltransferase 3; rRNA (uridine-2'-O-)-methyltransferase 3

NP_079586.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025310.3 → NP_079586.1 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

See identical proteins and their annotated locations for NP_079586.1

Status: VALIDATED

Source sequence(s)

AL604045

Consensus CDS

CCDS25552.1

UniProtKB/Swiss-Prot

Q3ULI1, Q921I7, Q9DBE9

Related

ENSMUSP00000021048.7, ENSMUST00000021048.7

Conserved Domains (3) summary

COG0293
Location:8 → 203

RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

pfam07780
Location:636 → 825

Spb1_C; Spb1 C-terminal domain

pfam11861
Location:232 → 398

DUF3381; Domain of unknown function (DUF3381)