Kcnq3 potassium voltage-gated channel subfamily Q member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnq3provided by RGD
Official Full Name: potassium voltage-gated channel subfamily Q member 3provided by RGD
Primary source: RGD:69222
See related: Ensembl:ENSRNOG00000005206 AllianceGenome:RGD:69222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including calmodulin binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Located in several cellular components, including axon initial segment; membrane raft; and neuronal cell body. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 146.3) and Adrenal (RPKM 16.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (99614089..99914736, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (97730219..98025652, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (106714479..107009639, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.
Title: Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.
The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
Title: The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
The key findings of the present study provide evidence emphasizing that lncRNA GAS5 functions as a competitive endogenous RNA of miR-135a-5p to increase expression of KCNQ3
Title: Long noncoding RNA GAS5 silencing inhibits the expression of KCNQ3 by sponging miR-135a-5p to prevent the progression of epilepsy.
KCNQ2 and KCNQ3 play an important role in neuronal differentiation of PC12 cells as measured by neurite growth. Depression of these KCNQs can promote neuronal differentiation, which is related to membrane depolarization and subsequent activation of Ca2+ influx through T type Ca2+ channels.
Title: Suppression of KV7/KCNQ potassium channel enhances neuronal differentiation of PC12 cells.
USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
Activity-dependent reduction of KCNQ2/KCNQ3 surface expression through ionotropic glutamate receptor activation/Ca(2+)/PKC signaling pathway might be an important molecular mechanism for regulation of neuronal excitability and synaptic plasticity
Title: Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron.
In neocortical myelinated axons Kv7.2/7.3 channels differentially regulate action potential initiation.
Title: Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.
Nevertheless, the present results suggest that selective openers of KV7.2/3 channels might be interesting candidates for the treatment of LID.
Title: The K(V)7.2/3 preferring channel opener ICA 27243 attenuates L-DOPA-induced dyskinesia in hemiparkinsonian rats.
Intratibial injection of MRMT-1 tumour cells decreased KCNQ3 expression & reduced M-current density in small-sized dorsal root ganglia, associated with enhanced excitability of these DRG neurons & hyperalgesic behaviour.
Title: Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.
Findings show that K(V)7/KCNQ channels were functionally expressed in primary cultured OLCs and might play an important role in OPCs functioning in physiological or pathological conditions.
Title: K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnq3 (e-PCR), detects polymorphism
- UniSTS:143685

AU046741 (e-PCR)
- UniSTS:111175

BF400035 (e-PCR)
- UniSTS:244820

D7Got81 (e-PCR)
- UniSTS:114543

BF390526 (e-PCR)
- UniSTS:249492

Kcnq3 (e-PCR), detects polymorphism
- UniSTS:259499

BE102380 (e-PCR)
- UniSTS:244148

RH144157 (e-PCR)
- UniSTS:233403

D7Rat18 (e-PCR)
- UniSTS:119023

BF416665 (e-PCR)
- UniSTS:249332

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in action potential initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within action potential initiation	ISO Inferred from Sequence Orthology more info
involved_in apoptosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptosome assembly	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ammonium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in excitatory chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
involved_in ganglion development	IEP Inferred from Expression Pattern more info	PubMed
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in inhibitory chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inhibitory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in nerve development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nerve development	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in psychomotor behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within psychomotor behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential firing threshold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of action potential firing threshold	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to auditory stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in substantia propria of cornea development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within substantia propria of cornea development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon initial segment	IBA Inferred from Biological aspect of Ancestor more info
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IEA Inferred from Electronic Annotation more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	IEA Inferred from Electronic Annotation more info
is_active_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 3

Names: KQT-like 3; potassium channel subunit alpha KvLQT3; potassium channel, voltage-gated KQT-like subfamily Q, member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; voltage-gated potassium channel subunit Kv7.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031597.5 → NP_113785.4 potassium voltage-gated channel subfamily KQT member 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O88944, Q9Z240

UniProtKB/TrEMBL

F1LPA2

Related

ENSRNOP00000093985.1, ENSRNOT00000109659.1

Conserved Domains (3) summary

pfam00520
Location:122 → 364

Ion_trans; Ion transport protein

pfam03520
Location:447 → 651

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:771 → 867

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

99614089..99914736 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263128.1 → XP_063119198.1 potassium voltage-gated channel subfamily KQT member 3 isoform X2
XM_063263127.1 → XP_063119197.1 potassium voltage-gated channel subfamily KQT member 3 isoform X1