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    Nifk nucleolar protein interacting with the FHA domain of MKI67 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246042, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nifkprovided by RGD
    Official Full Name
    nucleolar protein interacting with the FHA domain of MKI67provided by RGD
    Primary source
    RGD:708462
    See related
    Ensembl:ENSRNOG00000025701 AllianceGenome:RGD:708462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mki67ip
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in condensed nuclear chromosome; cytoplasm; and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human NIFK (nucleolar protein interacting with the FHA domain of MKI67). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 177.4), Spleen (RPKM 153.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (31946119..31955950)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (29393303..29403387)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (34267442..34277543)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene oocyte zinc finger protein XlCOF6-like Neighboring gene translin Neighboring gene 60S ribosomal protein L7-like Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 5 Neighboring gene cytoplasmic linker associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC105693

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MKI67 FHA domain-interacting nucleolar phosphoprotein
    Names
    Mki67 (FHA domain) interacting nucleolar phosphoprotein
    nucleolar protein interacting with the FHA domain of pKI-67
    spermatogenesis-related protein (Srp)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139186.2 → NP_631925.2  MKI67 FHA domain-interacting nucleolar phosphoprotein

      See identical proteins and their annotated locations for NP_631925.2

      Status: PROVISIONAL

      Source sequence(s)
      BC086585
      UniProtKB/Swiss-Prot
      Q5RJM0
      UniProtKB/TrEMBL
      A6K7V9
      Conserved Domains (2) summary
      pfam12196
      Location:206 → 242
      hNIFK_binding; FHA Ki67 binding domain of hNIFK
      cd12307
      Location:45 → 118
      RRM_NIFK_like; RNA recognition motif in nucleolar protein interacting with the FHA domain of pKI-67 (NIFK) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      31946119..31955950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598665.3 → XP_017454154.1  MKI67 FHA domain-interacting nucleolar phosphoprotein isoform X1

      UniProtKB/TrEMBL
      A0A8L2QSI2
      Related
      ENSRNOP00000058336.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJM0.1 GenPept UniProtKB/Swiss-Prot:Q5RJM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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