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    Bmp1 bone morphogenetic protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83470, updated on 2-May-2024

    Summary

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    Official Symbol
    Bmp1provided by RGD
    Official Full Name
    bone morphogenetic protein 1provided by RGD
    Primary source
    RGD:620739
    See related
    Ensembl:ENSRNOG00000010890 AllianceGenome:RGD:620739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within positive regulation of cartilage development. Located in extracellular space and vesicle. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 243.1), Liver (RPKM 137.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51961310..52005597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45551603..45595862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52166401..52210786, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene microRNA 320a Neighboring gene uncharacterized LOC120097030 Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein Neighboring gene uncharacterized LOC134482143 Neighboring gene surfactant protein C Neighboring gene leucine-rich repeat LGI family, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A regulatory role of androgen in ovarian steroidogenesis by rat granulosa cells. Hasegawa T, et al. J Steroid Biochem Mol Biol, 2017 Sep. PMID 28684382
    2. Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. Berry R, et al. Proc Natl Acad Sci U S A, 2009 May 26. PMID 19429706, Free PMC Article
    3. Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin. Zhang Y, et al. J Biol Chem, 2006 Dec 22. PMID 17071617
    4. bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Jasuja R, et al. Mech Dev, 2006 Jul. PMID 16824737
    5. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis. Grgurevic L, et al. J Am Soc Nephrol, 2011 Apr. PMID 21415150, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, the results indicate that androgen and IGF-I mutually interact and accelerate progesterone production, at least in part, by regulating endogenous BMP signaling in rat granulosa cells.
      Title: A regulatory role of androgen in ovarian steroidogenesis by rat granulosa cells.
    2. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
      Title: Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
    3. bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin
      Title: Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bone morphogenetic protein 1
    Names
    procollagen C-proteinase
    NP_112613.1
    XP_006252347.1
    XP_038949617.1
    XP_038949618.1
    XP_063130764.1
    XP_063130765.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031323.1 → NP_112613.1  bone morphogenetic protein 1 precursor

      See identical proteins and their annotated locations for NP_112613.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HTK6, F1M798
      Related
      ENSRNOP00000040287.4, ENSRNOT00000046054.5
      Conserved Domains (4) summary
      cd04281
      Location:125 → 324
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:439 → 548
      CUB; CUB domain
      pfam01400
      Location:132 → 325
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:711 → 746
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51961310..52005597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093690.2 → XP_038949618.1  bone morphogenetic protein 1 isoform X3

      UniProtKB/TrEMBL
      A6HTK7
      Conserved Domains (3) summary
      pfam00431
      Location:205 → 314
      CUB; CUB domain
      pfam14670
      Location:325 → 357
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00064
      Location:13 → 90
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    2. XM_006252285.3 → XP_006252347.1  bone morphogenetic protein 1 isoform X2

      UniProtKB/TrEMBL
      A6HTK7
      Conserved Domains (3) summary
      pfam00431
      Location:277 → 386
      CUB; CUB domain
      pfam14670
      Location:397 → 429
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00064
      Location:24 → 162
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    3. XM_039093689.2 → XP_038949617.1  bone morphogenetic protein 1 isoform X1

      Conserved Domains (3) summary
      cd04281
      Location:125 → 324
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:439 → 548
      CUB; CUB domain
      pfam14670
      Location:559 → 591
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_063274694.1 → XP_063130764.1  bone morphogenetic protein 1 isoform X4

    5. XM_063274695.1 → XP_063130765.1  bone morphogenetic protein 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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