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    Gabpb1 GA binding protein transcription factor subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499883, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gabpb1provided by RGD
    Official Full Name
    GA binding protein transcription factor subunit beta 1provided by RGD
    Primary source
    RGD:1560391
    See related
    Ensembl:ENSRNOG00000010659 AllianceGenome:RGD:1560391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560391
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in mitochondrion organization and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GABPB1 (GA binding protein transcription factor subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 113.0), Lung (RPKM 79.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gabpb1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134333339..134380239, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113879972..113924742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119091739..119135391, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 2 Neighboring gene histidine decarboxylase Neighboring gene small nucleolar RNA SNORA48 Neighboring gene cuticle collagen 40-like Neighboring gene uncharacterized LOC134486144 Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Ryu D, et al. Cell Metab, 2014 Nov 4. PMID 25200183
    2. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. Du K, et al. J Biol Chem, 1998 Dec 25. PMID 9857059
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GA-binding protein subunit beta-1
    Names
    GA binding protein transcription factor, beta subunit 1
    GA repeat binding protein, beta 1
    NP_001034125.1
    NP_001385852.1
    NP_001385853.1
    XP_008760411.1
    XP_008760412.1
    XP_017447471.1
    XP_017447472.1
    XP_017447473.1
    XP_038961617.1
    XP_063140441.1
    XP_063140442.1
    XP_063140443.1
    XP_063140444.1
    XP_063140445.1
    XP_063140446.1
    XP_063140447.1
    XP_063140448.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039036.2 → NP_001034125.1  GA-binding protein subunit beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001034125.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5B7, Q4KM28
      Related
      ENSRNOP00000078447.1, ENSRNOT00000109155.1
      Conserved Domains (3) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    2. NM_001398923.1 → NP_001385852.1  GA-binding protein subunit beta-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPY8
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:329 → 378
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    3. NM_001398924.1 → NP_001385853.1  GA-binding protein subunit beta-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5B7, A0A8I5ZWD2
      Conserved Domains (3) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134333339..134380239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105689.2 → XP_038961617.1  GA-binding protein subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A6HPY8
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:329 → 378
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    2. XM_063284375.1 → XP_063140445.1  GA-binding protein subunit beta-1 isoform X6

    3. XM_063284377.1 → XP_063140447.1  GA-binding protein subunit beta-1 isoform X8

    4. XM_017591984.3 → XP_017447473.1  GA-binding protein subunit beta-1 isoform X5

      Conserved Domains (3) summary
      sd00045
      Location:10 → 35
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10 → 92
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:264 → 313
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    5. XM_063284376.1 → XP_063140446.1  GA-binding protein subunit beta-1 isoform X7

    6. XM_017591983.3 → XP_017447472.1  GA-binding protein subunit beta-1 isoform X2

      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:328 → 377
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    7. XM_063284374.1 → XP_063140444.1  GA-binding protein subunit beta-1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K5B7

    8. XM_008762190.4 → XP_008760412.1  GA-binding protein subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5B7, A0A8I5ZWD2
      Related
      ENSRNOP00000083625.1
      Conserved Domains (3) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_063284372.1 → XP_063140442.1  GA-binding protein subunit beta-1 isoform X2

    10. XM_017591982.3 → XP_017447471.1  GA-binding protein subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A6HPY8
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:329 → 378
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    11. XM_063284373.1 → XP_063140443.1  GA-binding protein subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5B7, A0A8I5ZWD2

    12. XM_063284378.1 → XP_063140448.1  GA-binding protein subunit beta-1 isoform X9

    13. XM_008762189.3 → XP_008760411.1  GA-binding protein subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_008760411.1

      UniProtKB/TrEMBL
      A6HPY8
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:329 → 378
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    14. XM_063284371.1 → XP_063140441.1  GA-binding protein subunit beta-1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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