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    Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294324, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Agpat3provided by RGD
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 3provided by RGD
    Primary source
    RGD:1305787
    See related
    Ensembl:ENSRNOG00000001205 AllianceGenome:RGD:1305787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in endoplasmic reticulum. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 219.3), Brain (RPKM 213.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10330650..10415026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10330960..10415358)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11060584..11144806)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 1 Neighboring gene uncharacterized LOC120098853 Neighboring gene trafficking protein particle complex subunit 10 Neighboring gene PWP2, small subunit processome component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. Yuki K, et al. J Lipid Res, 2009 May. PMID 19114731, Free PMC Article
    2. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. Prasad SS, et al. J Lipid Res, 2011 Mar. PMID 21173190, Free PMC Article
    3. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
    NP_001099848.1
    XP_006256305.1
    XP_038954480.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106378.1 → NP_001099848.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

      See identical proteins and their annotated locations for NP_001099848.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473988
      UniProtKB/TrEMBL
      A6JK33, B0BNL8, G3V648
      Related
      ENSRNOP00000001602.5, ENSRNOT00000001602.6
      Conserved Domains (1) summary
      PLN02380
      Location:12 → 325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10330650..10415026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256243.5 → XP_006256305.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      See identical proteins and their annotated locations for XP_006256305.1

      UniProtKB/TrEMBL
      A6JK33, B0BNL8, G3V648
      Conserved Domains (1) summary
      PLN02380
      Location:12 → 325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    2. XM_039098552.2 → XP_038954480.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/TrEMBL
      A6JK33, B0BNL8, G3V648
      Conserved Domains (1) summary
      PLN02380
      Location:12 → 325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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