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    Iqce IQ motif containing E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304318, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Iqceprovided by RGD
    Official Full Name
    IQ motif containing Eprovided by RGD
    Primary source
    RGD:1311349
    See related
    Ensembl:ENSRNOG00000001241 AllianceGenome:RGD:1311349
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311349
    Summary
    Predicted to be involved in limb morphogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in ciliary membrane. Predicted to be extrinsic component of membrane. Predicted to be part of plasma membrane protein complex. Orthologous to human IQCE (IQ motif containing E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 102.7), Kidney (RPKM 27.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19057060..19096626)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13943290..13982708)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16030607..16069872)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene tweety family member 3 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing revealed a splice site variant in the IQCE gene underlying post-axial polydactyly type A restricted to lower limb. Umair M, et al. Eur J Hum Genet, 2017 Aug. PMID 28488682, Free PMC Article
    2. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, et al. Dev Cell, 2014 Mar 10. PMID 24582806, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of plasma membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    IQ domain-containing protein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19057060..19096626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598488.3 → XP_017453977.1  IQ domain-containing protein E isoform X1

    2. XM_017598489.3 → XP_017453978.1  IQ domain-containing protein E isoform X3

      Related
      ENSRNOP00000094917.1

    3. XM_017598490.3 → XP_017453979.1  IQ domain-containing protein E isoform X5

    4. XM_006248962.5 → XP_006249024.1  IQ domain-containing protein E isoform X2

      See identical proteins and their annotated locations for XP_006249024.1

      Conserved Domains (3) summary
      smart00015
      Location:561 → 581
      IQ; Calmodulin-binding motif
      pfam16043
      Location:423 → 477
      DUF4795; Domain of unknown function (DUF4795)
      pfam16046
      Location:347 → 478
      FAM76; FAM76 protein

    5. XM_063271863.1 → XP_063127933.1  IQ domain-containing protein E isoform X4

      UniProtKB/TrEMBL
      A0A8I6B1N9

    6. XM_221965.10 → XP_221965.5  IQ domain-containing protein E isoform X6

      See identical proteins and their annotated locations for XP_221965.5

      UniProtKB/TrEMBL
      D4ADQ3
      Related
      ENSRNOP00000040350.5
      Conserved Domains (3) summary
      smart00015
      Location:561 → 581
      IQ; Calmodulin-binding motif
      pfam16043
      Location:423 → 477
      DUF4795; Domain of unknown function (DUF4795)
      pfam16046
      Location:347 → 478
      FAM76; FAM76 protein

    7. XM_017598491.3 → XP_017453980.1  IQ domain-containing protein E isoform X7

      Related
      ENSRNOP00000001667.7

    8. XM_063271865.1 → XP_063127935.1  IQ domain-containing protein E isoform X9

    9. XM_063271866.1 → XP_063127936.1  IQ domain-containing protein E isoform X12

    10. XM_063271864.1 → XP_063127934.1  IQ domain-containing protein E isoform X8

      UniProtKB/TrEMBL
      D3ZUL9

    11. XM_039089960.2 → XP_038945888.1  IQ domain-containing protein E isoform X10

      UniProtKB/TrEMBL
      A6K1R7
      Conserved Domains (2) summary
      smart00015
      Location:516 → 536
      IQ; Calmodulin-binding motif
      COG1196
      Location:167 → 465
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_063271867.1 → XP_063127937.1  IQ domain-containing protein E isoform X13

    13. XM_039089961.2 → XP_038945889.1  IQ domain-containing protein E isoform X17

      Conserved Domains (2) summary
      smart00015
      Location:563 → 584
      IQ; Calmodulin-binding motif
      COG1196
      Location:212 → 510
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. XM_063271870.1 → XP_063127940.1  IQ domain-containing protein E isoform X18

    15. XM_017598492.3 → XP_017453981.1  IQ domain-containing protein E isoform X11

    16. XM_017598494.3 → XP_017453983.1  IQ domain-containing protein E isoform X19

    17. XM_063271872.1 → XP_063127942.1  IQ domain-containing protein E isoform X21

    18. XM_017598493.3 → XP_017453982.1  IQ domain-containing protein E isoform X14

    19. XM_063271868.1 → XP_063127938.1  IQ domain-containing protein E isoform X15

    20. XM_063271869.1 → XP_063127939.1  IQ domain-containing protein E isoform X16

    21. XM_063271871.1 → XP_063127941.1  IQ domain-containing protein E isoform X20

    Nucleotide Protein Strain
    Heading Accession and Version

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