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    Ralgdsl1 ral guanine nucleotide dissociation stimulator like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289080, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ralgdsl1provided by RGD
    Official Full Name
    ral guanine nucleotide dissociation stimulator like 1provided by RGD
    Primary source
    RGD:1308947
    See related
    Ensembl:ENSRNOG00000002347 AllianceGenome:RGD:1308947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rgl1
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Orthologous to human RGL1 (ral guanine nucleotide dissociation stimulator like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 162.6), Heart (RPKM 100.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67184402..67454019, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (64634489..64904170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (69909122..70174590, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene uncharacterized LOC102551528 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene uncharacterized LOC134481515 Neighboring gene actin related protein 2/3 complex, subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105957.2 → NP_001099427.2  ral guanine nucleotide dissociation stimulator-like 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICT7, D3ZS31
      Related
      ENSRNOP00000063014.2, ENSRNOT00000067135.2
      Conserved Domains (3) summary
      smart00229
      Location:100 → 231
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:263 → 532
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:682 → 768
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      67184402..67454019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272095.1 → XP_063128165.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGN1

    2. XM_017598701.3 → XP_017454190.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      UniProtKB/TrEMBL
      A6ICT7, D3ZS31
      Conserved Domains (3) summary
      smart00229
      Location:100 → 231
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:263 → 532
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:682 → 768
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    3. XM_008769610.4 → XP_008767832.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGN1, A6ICT7
      Related
      ENSRNOP00000092177.1
      Conserved Domains (3) summary
      cd00153
      Location:646 → 731
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:63 → 194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:226 → 495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    4. XM_006249982.5 → XP_006250044.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

      See identical proteins and their annotated locations for XP_006250044.1

      UniProtKB/TrEMBL
      A6ICT6, A6ICT7
      Related
      ENSRNOP00000069394.2
      Conserved Domains (3) summary
      cd00153
      Location:648 → 733
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:65 → 196
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:228 → 497
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    5. XM_039090443.2 → XP_038946371.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X4

      Conserved Domains (3) summary
      smart00229
      Location:100 → 231
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:263 → 532
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cl28922
      Location:682 → 703
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. XM_063272096.1 → XP_063128166.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JV91
    Nucleotide Protein Strain
    Heading Accession and Version

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