U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ERICH6B glutamate rich 6B [ Homo sapiens (human) ]

    Gene ID: 220081, updated on 17-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ERICH6Bprovided by HGNC
    Official Full Name
    glutamate rich 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:26523
    See related
    Ensembl:ENSG00000165837 AllianceGenome:HGNC:26523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM194B
    Expression
    Restricted expression toward testis (RPKM 1.6) See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ERICH6B in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45541294..45615739, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44762627..44837047, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46115429..46189874, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 25 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:46058676-46059178 Neighboring gene component of oligomeric golgi complex 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46114323-46114822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46115537-46116388 Neighboring gene RNA, 5S ribosomal pseudogene 27 Neighboring gene TIMM9 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46189497-46189998 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:46232427-46233626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:46243444-46244066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46254125-46254627 Neighboring gene cytochrome c oxidase subunit 4I1 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 1055 Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. Meng X, et al. J Biol Chem, 2012 Feb 10. PMID 22199357, Free PMC Article
    2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
    3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Giurato G, et al. Sci Data, 2018 Mar 6. PMID 29509190, Free PMC Article
    4. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of family with sequence similarity 194, member B (FAM194B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ32682

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate-rich protein 6B
    Names
    family with sequence similarity 194, member B
    protein FAM194B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182542.3 → NP_872348.2  glutamate-rich protein 6B

      See identical proteins and their annotated locations for NP_872348.2

      Status: VALIDATED

      Source sequence(s)
      AL139326
      Consensus CDS
      CCDS45045.1
      UniProtKB/Swiss-Prot
      Q5W0A0, Q96MB5
      Related
      ENSP00000298738.2, ENST00000298738.3
      Conserved Domains (1) summary
      pfam14977
      Location:472 → 666
      FAM194; FAM194 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      45541294..45615739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020418.2 → XP_016875907.1  glutamate-rich protein 6B isoform X2

      UniProtKB/Swiss-Prot
      Q5W0A0, Q96MB5
      Conserved Domains (1) summary
      pfam14977
      Location:472 → 666
      FAM194; FAM194 protein

    2. XM_011534965.3 → XP_011533267.1  glutamate-rich protein 6B isoform X1

      See identical proteins and their annotated locations for XP_011533267.1

      Conserved Domains (1) summary
      pfam14977
      Location:472 → 690
      FAM194; FAM194 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      44762627..44837047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374192.1 → XP_054230167.1  glutamate-rich protein 6B isoform X2

    2. XM_054374191.1 → XP_054230166.1  glutamate-rich protein 6B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5W0A0.1 GenPept UniProtKB/Swiss-Prot:Q5W0A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools