TRIB3 tribbles pseudokinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIB3provided by HGNC
Official Full Name: tribbles pseudokinase 3provided by HGNC
Primary source: HGNC:HGNC:16228
See related: Ensembl:ENSG00000101255 MIM:607898; AllianceGenome:HGNC:16228
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NIPK; SINK; TRB3; SKIP3; C20orf97
Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (380760..397559)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (424107..440963)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (361404..378203)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4alpha stability.
Title: TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4α stability.
TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2.
Title: TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2.
TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.
Title: TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.
Integration of dietary nutrition and TRIB3 action into diabetes mellitus.
Title: Integration of dietary nutrition and TRIB3 action into diabetes mellitus.
TRIB3, as a robust prognostic biomarker for HNSC, is associated with poor immune infiltration and cancer cell immune evasion.
Title: TRIB3, as a robust prognostic biomarker for HNSC, is associated with poor immune infiltration and cancer cell immune evasion.
Transcription Factor Sox9 Exacerbates Kidney Injury through Inhibition of MicroRNA-96-5p and Activation of the Trib3/IL-6 Axis.
Title: Transcription Factor Sox9 Exacerbates Kidney Injury through Inhibition of MicroRNA-96-5p and Activation of the Trib3/IL-6 Axis.
A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
Title: A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
Upregulation of Tribbles decreases body weight and increases sleep duration.
Title: Upregulation of Tribbles decreases body weight and increases sleep duration.
The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.
Title: The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF.
Title: TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF.

Submit: New GeneRIF Correction See all GeneRIFs (124)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z94712 (e-PCR)
- UniSTS:48034

STS-U02019 (e-PCR)
- UniSTS:49608

WI-15969 (e-PCR)
- UniSTS:68064

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ubiquitin-protein transferase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tribbles homolog 3

Names: TRB-3; neuronal cell death inducible putative kinase; p65-interacting inhibitor of NF-kappa-B; p65-interacting inhibitor of NF-kappaB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301188.1 → NP_001288117.1 tribbles homolog 3 isoform 1

See identical proteins and their annotated locations for NP_001288117.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as 1B1) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.

Source sequence(s)

AJ697936, AJ697937, BC019363

Consensus CDS

CCDS12997.1

UniProtKB/Swiss-Prot

Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2

UniProtKB/TrEMBL

B4DMM9

Related

ENSP00000519697.1, ENST00000714428.1

Conserved Domains (1) summary

cd14024
Location:74 → 315

PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
NM_001301190.1 → NP_001288119.1 tribbles homolog 3 isoform 1

See identical proteins and their annotated locations for NP_001288119.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as 1B2) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.

Source sequence(s)

AJ697936, AJ697938, BC019363

Consensus CDS

CCDS12997.1

UniProtKB/Swiss-Prot

Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2

UniProtKB/TrEMBL

B4DMM9

Related

ENSP00000519696.1, ENST00000714427.1

Conserved Domains (1) summary

cd14024
Location:74 → 315

PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
NM_001301193.1 → NP_001288122.1 tribbles homolog 3 isoform 1

See identical proteins and their annotated locations for NP_001288122.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as 1B3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.

Source sequence(s)

AJ697936, AJ697939, BC019363

Consensus CDS

CCDS12997.1

UniProtKB/Swiss-Prot

Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2

UniProtKB/TrEMBL

B4DMM9

Conserved Domains (1) summary

cd14024
Location:74 → 315

PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
NM_001301196.1 → NP_001288125.1 tribbles homolog 3 isoform 1

See identical proteins and their annotated locations for NP_001288125.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as 1B4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.

Source sequence(s)

AJ697936, AJ697940, BC019363

Consensus CDS

CCDS12997.1

UniProtKB/Swiss-Prot

Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2

UniProtKB/TrEMBL

B4DMM9

Related

ENSP00000391873.2, ENST00000449710.6

Conserved Domains (1) summary

cd14024
Location:74 → 315

PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
NM_001301201.1 → NP_001288130.1 tribbles homolog 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate 5' UTR exon and an additional exon in the 5' region, which results in an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.

Source sequence(s)

AJ697940, AK297546, BC019363

Consensus CDS

CCDS77554.1

UniProtKB/TrEMBL

B4DMM9, J3KR25

Related

ENSP00000415416.2, ENST00000422053.3

Conserved Domains (2) summary

smart00220
Location:107 → 342

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14024
Location:101 → 342

PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
NM_021158.5 → NP_066981.2 tribbles homolog 3 isoform 1

See identical proteins and their annotated locations for NP_066981.2

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as 1A) represents the longest transcript and encode the predominant isoform (1).

Source sequence(s)

AL034548

Consensus CDS

CCDS12997.1

UniProtKB/Swiss-Prot

Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2

UniProtKB/TrEMBL

B4DMM9

Related

ENSP00000217233.3, ENST00000217233.9

Conserved Domains (1) summary

cd14024
Location:74 → 315

PK_TRB3; Pseudokinase domain of Tribbles Homolog 3