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    STRA8 stimulated by retinoic acid 8 [ Homo sapiens (human) ]

    Gene ID: 346673, updated on 6-Jun-2024

    Summary

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    Official Symbol
    STRA8provided by HGNC
    Official Full Name
    stimulated by retinoic acid 8provided by HGNC
    Primary source
    HGNC:HGNC:30653
    See related
    Ensembl:ENSG00000146857 MIM:609987; AllianceGenome:HGNC:30653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See STRA8 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135231915..135258663)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136539792..136566564)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134916667..134943415)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26714 Neighboring gene solute carrier family 23 member 4, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134998844-134999016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135023371-135023872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135023873-135024372 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:135032494-135032998 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:135065068-135065648 Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene succinate dehydrogenase complex subunit D pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. Le Bouffant R, et al. Hum Reprod, 2010 Oct. PMID 20670969
    2. [Genetics and male infertility]. Stouffs K, et al. Verh K Acad Geneeskd Belg, 2009. PMID 20088251
    3. Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells. Chen B, et al. Asian J Androl, 2009 Sep. PMID 19734913, Free PMC Article
    4. Global gene expression in the human fetal testis and ovary. Houmard B, et al. Biol Reprod, 2009 Aug. PMID 19369649, Free PMC Article
    5. Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Anderson EL, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18799751, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro.
      Title: Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro.
    2. The genetic variant rs10269148 of STRA8 gene shows higher risk of spermatogenic impairment in the groups of abnormospermia than the controls
      Title: Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.
    3. Functional characterization of an homologous mouse gene.
      Title: Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
    5. Expression restricted to testis (STRA8)
      Title: Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    stimulated by retinoic acid gene 8 protein homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394401.1 → NP_001381330.1  stimulated by retinoic acid gene 8 protein homolog isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009542
      Consensus CDS
      CCDS94209.1
      UniProtKB/Swiss-Prot
      Q7Z7C7
      UniProtKB/TrEMBL
      A0A590UJF1
      Related
      ENSP00000499386.1, ENST00000662584.2
      Conserved Domains (1) summary
      cl00081
      Location:31 → 90
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    2. NM_182489.3 → NP_872295.2  stimulated by retinoic acid gene 8 protein homolog isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009542
      Consensus CDS
      CCDS5839.2
      UniProtKB/Swiss-Prot
      Q7Z7C7
      UniProtKB/TrEMBL
      A0A590UK75
      Related
      ENSP00000499721.1, ENST00000667288.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      135231915..135258663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516137.3 → XP_011514439.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

      See identical proteins and their annotated locations for XP_011514439.1

      UniProtKB/Swiss-Prot
      Q7Z7C7
      UniProtKB/TrEMBL
      A0A590UJF1
      Conserved Domains (1) summary
      cl00081
      Location:31 → 90
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    2. XM_047420324.1 → XP_047276280.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

      UniProtKB/Swiss-Prot
      Q7Z7C7
      UniProtKB/TrEMBL
      A0A590UJF1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136539792..136566564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358113.1 → XP_054214088.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

      UniProtKB/Swiss-Prot
      Q7Z7C7

    2. XM_054358114.1 → XP_054214089.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

      UniProtKB/Swiss-Prot
      Q7Z7C7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7C7.1 GenPept UniProtKB/Swiss-Prot:Q7Z7C7

    Gene LinkOut

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