Htra1 HtrA serine peptidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htra1provided by MGI
Official Full Name: HtrA serine peptidase 1provided by MGI
Primary source: MGI:MGI:1929076
See related: Ensembl:ENSMUSG00000006205 AllianceGenome:MGI:1929076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L56; HTRA; Prss11; RSPP11
Summary: Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; limb; reproductive system; sensory organ; and skin. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 297.0), mammary gland adult (RPKM 75.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 73.2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (130537933..130587388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (130936203..130985658)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy.
Title: HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy.
Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice.
Title: Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice.
HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid.
Title: HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid.
HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF-beta/Smad signaling pathway in CARASIL model mice.
Title: HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF-β/Smad signaling pathway in CARASIL model mice.
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Title: Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Placental HTRA1 cleaves alpha1-antitrypsin to generate a NET-inhibitory peptide.
Title: Placental HTRA1 cleaves α1-antitrypsin to generate a NET-inhibitory peptide.
RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers.
Title: RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers.
Loss of the serine protease HTRA1 impairs smooth muscle cells maturation.
Title: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation.
Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells.
Title: Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells.
OCs secrete HtrA1 as an OPG-degrading enzyme. HtrA1 recognized the three-dimensional structure of OPG; it initially cleaved the amide bond between leucine 90 and glutamine 91 of OPG, and then degraded OPG into small fragments.
Title: Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (5) 1 citation
Gene trapped (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htra1 (e-PCR), detects polymorphism
- UniSTS:498796

AI429470 (e-PCR)
- UniSTS:159705

D7Mit136 (e-PCR), detects polymorphism
- UniSTS:131035

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chorionic trophoblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in programmed cell death	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease HTRA1

Names: high-temperature requirement A serine peptidase 1; insulin-like growth factor binding protein 5 protease; protease, serine, 11 (Igf binding); serine protease 11

NP_062510.2

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019564.3 → NP_062510.2 serine protease HTRA1 precursor

See identical proteins and their annotated locations for NP_062510.2

Status: VALIDATED

Source sequence(s)

AF179369, AI429470, CB193609

Consensus CDS

CCDS21908.1

UniProtKB/Swiss-Prot

Q8BN04, Q8BN05, Q91WS3, Q9QZK6, Q9R118

Related

ENSMUSP00000006367.8, ENSMUST00000006367.8

Conserved Domains (5) summary

smart00121
Location:37 → 111

IB; Insulin growth factor-binding protein homologues

smart00280
Location:115 → 155

KAZAL; Kazal type serine protease inhibitors

COG0265
Location:154 → 480

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00987
Location:382 → 473

PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...

pfam13365
Location:204 → 342

Trypsin_2; Trypsin-like peptidase domain