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    Coro2a coronin, actin binding protein 2A [ Mus musculus (house mouse) ]

    Gene ID: 107684, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Coro2aprovided by MGI
    Official Full Name
    coronin, actin binding protein 2Aprovided by MGI
    Primary source
    MGI:MGI:1345966
    See related
    Ensembl:ENSMUSG00000028337 AllianceGenome:MGI:1345966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IR10; 9030208C03Rik
    Summary
    Predicted to enable actin filament binding activity. Located in brush border. Is expressed in several structures, including alimentary system; nervous system; nose; spleen; and testis. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 92.0), colon adult (RPKM 68.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B1; 4 24.87 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46536937..46601929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46536937..46601929, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3487 Neighboring gene predicted gene, 22247 Neighboring gene N-acetylneuraminic acid synthase (sialic acid synthase) Neighboring gene tripartite motif-containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E3488 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene STARR-positive B cell enhancer ABC_E4623 Neighboring gene STARR-positive B cell enhancer ABC_E3489 Neighboring gene STARR-positive B cell enhancer ABC_E3490 Neighboring gene predicted gene, 54221 Neighboring gene STARR-positive B cell enhancer ABC_E6173 Neighboring gene predicted gene, 54222 Neighboring gene STARR-positive B cell enhancer ABC_E2111 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 31850 Neighboring gene predicted gene, 42281

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Huang W, et al. Nature, 2011 Feb 17. PMID 21331046, Free PMC Article
    2. The coronin family of actin-associated proteins. de Hostos EL. Trends Cell Biol, 1999 Sep. PMID 10461187
    3. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. Okumura M, et al. DNA Cell Biol, 1998 Sep. PMID 9778037
    4. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Suo D, et al. Nat Neurosci, 2014 Jan. PMID 24270184, Free PMC Article
    5. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coronin-2A
    Names
    coronin 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164804.1 → NP_001158276.1  coronin-2A isoform 2

      See identical proteins and their annotated locations for NP_001158276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK030971, AK054394, AL683884, AW912496
      Consensus CDS
      CCDS18154.1
      UniProtKB/Swiss-Prot
      Q3U6H8, Q8BW42, Q8C0P5
      UniProtKB/TrEMBL
      B1AVH4, Q3U4G8
      Related
      ENSMUSP00000103385.3, ENSMUST00000107756.4
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_178893.4 → NP_849224.2  coronin-2A isoform 1

      See identical proteins and their annotated locations for NP_849224.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK030097, AK030971, AL683884
      Consensus CDS
      CCDS71383.1
      UniProtKB/TrEMBL
      B1AVH5, Q3U4G8
      Related
      ENSMUSP00000103386.2, ENSMUST00000107757.8
      Conserved Domains (2) summary
      sd00039
      Location:59 → 99
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29 → 536
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      46536937..46601929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163567.1 → XP_036019460.1  coronin-2A isoform X2

      UniProtKB/Swiss-Prot
      Q3U6H8, Q8BW42, Q8C0P5
      UniProtKB/TrEMBL
      B1AVH4, Q3U4G8
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_011249899.4 → XP_011248201.1  coronin-2A isoform X1

      See identical proteins and their annotated locations for XP_011248201.1

      UniProtKB/TrEMBL
      B1AVH5, Q3U4G8
      Conserved Domains (2) summary
      sd00039
      Location:59 → 99
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29 → 536
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0P5.1 GenPept UniProtKB/Swiss-Prot:Q8C0P5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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