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    SNHG12 small nucleolar RNA host gene 12 [ Homo sapiens (human) ]

    Gene ID: 85028, updated on 12-Feb-2024

    Summary

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    Official Symbol
    SNHG12provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 12provided by HGNC
    Primary source
    HGNC:HGNC:30062
    See related
    Ensembl:ENSG00000197989 AllianceGenome:HGNC:30062
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf79; PNAS-123; LINC00100; ASLNC04080; NCRNA00100
    Summary
    This gene produces a long RNA that is overexpressed in tumor cells. This RNA may promote tumorigenesis by acting as a sponge for microRNAs. [provided by RefSeq, Dec 2017]
    Expression
    Ubiquitous expression in appendix (RPKM 11.0), spleen (RPKM 10.5) and 25 other tissues See more
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    Genomic context

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    See SNHG12 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28578538..28582983, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28420494..28424939, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28905050..28909495, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28844515-28845366 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28845367-28846217 Neighboring gene regulator of chromosome condensation 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28850571-28851072 Neighboring gene peroxiredoxin 3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28866050-28866550 Neighboring gene Sharpr-MPRA regulatory region 11844 Neighboring gene Sharpr-MPRA regulatory region 11894 Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28907091-28907876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28907877-28908662 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA, H/ACA box 61 Neighboring gene small nucleolar RNA, H/ACA box 44 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28919769-28920505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28925585-28926166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28928951-28929451 Neighboring gene RAB42, member RAS oncogene family Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene Sharpr-MPRA regulatory region 12118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28971631-28972130 Neighboring gene TAF12 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP. Tan D, et al. Ann Clin Lab Sci, 2023 Jan. PMID 36889771
    2. Identification of stemness index-related long noncoding RNA SNHG12 in human bladder cancer based on WGCNA. Zhang B, et al. Mol Cell Probes, 2022 Dec. PMID 36183925
    3. LncRNA SNHG12 Promotes Osteoarthritis Progression Through Targeted Down-Regulation of miR-16-5p. Yang X, et al. Clin Lab, 2022 Jan 1. PMID 35023690
    4. LncRNA SNHG12 in extracellular vesicles derived from carcinoma-associated fibroblasts promotes cisplatin resistance in non-small cell lung cancer cells. Tan D, et al. Bioengineered, 2022 Jan. PMID 35014944, Free PMC Article
    5. Silencing of lncRNA SNHG12 inhibits proliferation and migration of vascular smooth muscle cells via targeting miR-766-5p/EIF5A axis. Liu W, et al. Adv Clin Exp Med, 2021 Jun. PMID 34018346

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
      Title: The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
    2. LncRNA SNHG12: A budding star in human diseases.
      Title: LncRNA SNHG12: A budding star in human diseases.
    3. LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP.
      Title: LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP.
    4. Identification of stemness index-related long noncoding RNA SNHG12 in human bladder cancer based on WGCNA.
      Title: Identification of stemness index-related long noncoding RNA SNHG12 in human bladder cancer based on WGCNA.
    5. Molecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis.
      Title: Molecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis.
    6. LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p.
      Title: LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p.
    7. YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.
      Title: YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.
    8. LncRNA SNHG12 regulates ox-LDL-induced endothelial cell injury by the miR-218-5p/IGF2 axis in atherosclerosis.
      Title: LncRNA SNHG12 regulates ox-LDL-induced endothelial cell injury by the miR-218-5p/IGF2 axis in atherosclerosis.
    9. LncRNA SNHG12 in extracellular vesicles derived from carcinoma-associated fibroblasts promotes cisplatin resistance in non-small cell lung cancer cells.
      Title: LncRNA SNHG12 in extracellular vesicles derived from carcinoma-associated fibroblasts promotes cisplatin resistance in non-small cell lung cancer cells.
    10. Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson's disease.
      Title: Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 100
    • small nucleolar RNA host gene 12 (non-protein coding)

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024127.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC068048, CB128668

    2. NR_146381.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC045792, CB128668
      Related
      ENST00000470977.6

    3. NR_146382.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC022205, BC045792
      Related
      ENST00000488745.5

    4. NR_146383.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC045792, BU947373, CB128668
      Related
      ENST00000531126.7

    5. NR_146384.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL513497
      Related
      ENST00000461832.2

    6. NR_146385.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL513497
      Related
      ENST00000481220.6

    7. NR_146386.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL513497
      Related
      ENST00000483436.5

    8. NR_146387.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL513497

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      28578538..28582983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      28420494..28424939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials