Defb12 defensin beta 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defb12provided by MGI
Official Full Name: defensin beta 12provided by MGI
Primary source: MGI:MGI:1924924
See related: Ensembl:ENSMUSG00000043787 AllianceGenome:MGI:1924924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BD-12; 9230103N16Rik
Summary: Acts upstream of or within defense response to Gram-negative bacterium. Predicted to be located in extracellular region. Orthologous to several human genes including DEFB105B (defensin beta 105B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 121.5) See more
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Genomic context

Location:: 8 A1.3; 8 10.35 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (19161947..19164850, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (19111931..19114833, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The epididymis-specific expression pattern of beta-defensin isoform mBD-12 has been characterized.
Title: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-defensin 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152802.4 → NP_690015.2 beta-defensin 12 precursor

Status: VALIDATED

Source sequence(s)

AC116394

Consensus CDS

CCDS52496.1

UniProtKB/Swiss-Prot

Q8K4N3

UniProtKB/TrEMBL

A0A0R4J0S5

Related

ENSMUSP00000060899.9, ENSMUST00000062113.9

Conserved Domains (1) summary

pfam13841
Location:45 → 74

Defensin_beta_2; Beta defensin