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    DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 [ Homo sapiens (human) ]

    Gene ID: 23234, updated on 5-May-2024

    Summary

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    Official Symbol
    DNAJC9provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C9provided by HGNC
    Primary source
    HGNC:HGNC:19123
    See related
    Ensembl:ENSG00000213551 MIM:611206; AllianceGenome:HGNC:19123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JDD1; SB73; HDJC9
    Summary
    Enables chaperone binding activity; heat shock protein binding activity; and histone binding activity. Involved in nucleosome assembly and positive regulation of ATPase activity. Located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 34.5), lymph node (RPKM 15.2) and 24 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    10q22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73232272..73247255, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74100932..74118636, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75001712..75007013, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 149 member B1 Neighboring gene uncharacterized LOC105378358 Neighboring gene NANOG hESC enhancer GRCh37_chr10:74965967-74966502 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75006455-75007654 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:75012121-75012688 Neighboring gene DNAJC9 and MRPS16 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75015484-75015659 Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene cilia and flagella associated protein 70 Neighboring gene RNA, U6 small nuclear 833, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. JDD1, a novel member of the DnaJ family, is expressed in the germinal zone of the rat brain. Takamura Y, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444854
    2. Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization. Pan Z, et al. Neoplasma, 2010. PMID 20099975
    3. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. Liu CM, et al. Biol Psychiatry, 2011 Jul 1. PMID 21531385
    4. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. Han C, et al. Biochem Biophys Res Commun, 2007 Feb 9. PMID 17182002
    5. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction. Dhamad AE, et al. PLoS One, 2016. PMID 27483141, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
      Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
    2. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
      Title: ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Up-regulation of DNAJC9 is associated with cervical squamous cell carcinoma.
      Title: Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0974

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein folding chaperone complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 9
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 9
    DnaJ protein SB73

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015190.5 → NP_056005.1  dnaJ homolog subfamily C member 9

      See identical proteins and their annotated locations for NP_056005.1

      Status: VALIDATED

      Source sequence(s)
      BC136507, BQ002383, BQ954888, BX646217, DA819115
      Consensus CDS
      CCDS7322.1
      UniProtKB/Swiss-Prot
      B2RMW6, Q8WXX5
      UniProtKB/TrEMBL
      Q2VIL4
      Related
      ENSP00000362041.4, ENST00000372950.6
      Conserved Domains (1) summary
      pfam00226
      Location:15 → 79
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73232272..73247255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424909.1 → XP_047280865.1  dnaJ homolog subfamily C member 9 isoform X1

    2. XM_047424908.1 → XP_047280864.1  dnaJ homolog subfamily C member 9 isoform X1

    RNA

    1. XR_007061950.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74100932..74118636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365348.1 → XP_054221323.1  dnaJ homolog subfamily C member 9 isoform X1

    2. XM_054365347.1 → XP_054221322.1  dnaJ homolog subfamily C member 9 isoform X1

    RNA

    1. XR_008488186.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WXX5.1 GenPept UniProtKB/Swiss-Prot:Q8WXX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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