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    FAM215A family with sequence similarity 215 member A [ Homo sapiens (human) ]

    Gene ID: 23591, updated on 12-Feb-2024

    Summary

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    Official Symbol
    FAM215Aprovided by HGNC
    Official Full Name
    family with sequence similarity 215 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:17505
    See related
    Ensembl:ENSG00000267496 AllianceGenome:HGNC:17505
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APR-2; C17orf88; LINC00530
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    Genomic context

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    Location:
    17q21.31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43917208..43917987)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44769753..44770532)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41994576..41995355)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985077 Neighboring gene CD300 molecule like family member g Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41943686-41943858 Neighboring gene Sharpr-MPRA regulatory region 5434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959115-41959616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959617-41960116 Neighboring gene MAGUK p55 scaffold protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41991041-41991541 Neighboring gene uncharacterized LOC105371787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41994398-41995219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41995220-41996040 Neighboring gene uncharacterized LOC107985086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41997678-41998178 Neighboring gene leucine rich repeat containing 37 member A10, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer. Huang PS, et al. Cells, 2020 Apr 14. PMID 32295144, Free PMC Article
    2. Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer. Fu Y, et al. Gynecol Oncol, 2016 Dec. PMID 27667152, Free PMC Article
    3. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. Zhu F, et al. Biotechniques, 2000 Aug. PMID 10948432
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.
      Title: Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.
    2. Up-regulation of BOK-AS1, FAM215A and FEZF1-AS1 lncRNAs and their potency as moderate diagnostic biomarkers in gastric cancer.
      Title: Up-regulation of BOK-AS1, FAM215A and FEZF1-AS1 lncRNAs and their potency as moderate diagnostic biomarkers in gastric cancer.
    3. Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer.
      Title: Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • apoptosis related protein
    • family with sequence similarity 215 member A (non-protein coding)
    • long intergenic non-protein coding RNA 530

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026770.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC069097, DA188505
      Related
      ENST00000632077.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43917208..43917987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44769753..44770532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014318.2: Suppressed sequence

      Description
      NM_014318.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5M1.2 GenPept UniProtKB/Swiss-Prot:Q9Y5M1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
    Miscellaneous