Npas4 neuronal PAS domain protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npas4provided by MGI
Official Full Name: neuronal PAS domain protein 4provided by MGI
Primary source: MGI:MGI:2664186
See related: Ensembl:ENSMUSG00000045903 AllianceGenome:MGI:2664186
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nxf; LE-PAS
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including inhibitory synapse assembly; learning or memory; and modulation of chemical synaptic transmission. Acts upstream of or within cellular response to corticosterone stimulus; inhibitory postsynaptic potential; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in bladder; brain; embryo; ureter; and urethra of female. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 3.6), cortex adult (RPKM 2.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.2 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5034381..5053467, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4984353..5003439, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in Mice.
Title: NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in Mice.
NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses.
Title: NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses.
Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning.
Title: Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning.
Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion.
Title: Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion.
Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
Title: Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice.
Title: Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice.
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Title: Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells.
Title: NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells.
NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior.
Title: NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior.
Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release.
Title: Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_12329-12330:1005768102:1 (e-PCR)
- UniSTS:267415

MARC_12329-12330:1017158939:3 (e-PCR)
- UniSTS:267415

Npas4 (e-PCR), detects polymorphism
- UniSTS:545972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to acid chemical	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to corticosterone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuronal PAS domain-containing protein 4

Names: HLH-PAS transcription factor NXF; bHLH-PAS type transcription factor NXF; limbic-enhanced PAS protein; neuronal PAS4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153553.5 → NP_705781.1 neuronal PAS domain-containing protein 4

See identical proteins and their annotated locations for NP_705781.1

Status: VALIDATED

Source sequence(s)

AC124502

Consensus CDS

CCDS29445.1

UniProtKB/Swiss-Prot

Q3V3U3, Q8BGD7

UniProtKB/TrEMBL

A1L327

Related

ENSMUSP00000062992.8, ENSMUST00000056129.9

Conserved Domains (3) summary

smart00091
Location:72 → 135

PAS; PAS domain

pfam08447
Location:230 → 298

PAS_3; PAS fold

cd19697
Location:2 → 57

bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5034381..5053467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161526.1 → XP_036017419.1 neuronal PAS domain-containing protein 4 isoform X1

UniProtKB/Swiss-Prot

Q3V3U3, Q8BGD7

UniProtKB/TrEMBL

A1L327

Conserved Domains (3) summary

smart00091
Location:72 → 135

PAS; PAS domain

pfam08447
Location:230 → 298

PAS_3; PAS fold

cd19697
Location:2 → 57

bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins
XM_011248619.3 → XP_011246921.1 neuronal PAS domain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_011246921.1

UniProtKB/Swiss-Prot

Q3V3U3, Q8BGD7

UniProtKB/TrEMBL

A1L327

Conserved Domains (3) summary

smart00091
Location:72 → 135

PAS; PAS domain

pfam08447
Location:230 → 298

PAS_3; PAS fold

cd19697
Location:2 → 57

bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins
XM_030250872.2 → XP_030106732.1 neuronal PAS domain-containing protein 4 isoform X1

UniProtKB/Swiss-Prot

Q3V3U3, Q8BGD7

UniProtKB/TrEMBL

A1L327

Conserved Domains (3) summary

smart00091
Location:72 → 135

PAS; PAS domain

pfam08447
Location:230 → 298

PAS_3; PAS fold

cd19697
Location:2 → 57

bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins