HECA hdc homolog, cell cycle regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: HECAprovided by HGNC
Official Full Name: hdc homolog, cell cycle regulatorprovided by HGNC
Primary source: HGNC:HGNC:21041
See related: Ensembl:ENSG00000112406 MIM:607977; AllianceGenome:HGNC:21041
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HDC; HDCL; HHDC; dJ225E12.1
Summary: This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 16.9), spleen (RPKM 16.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q24.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (139135080..139180802)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (140323625..140369329)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (139456217..139501939)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional analysis of HECA variants identified in congenital heart disease in the Chinese population.
Title: Functional analysis of HECA variants identified in congenital heart disease in the Chinese population.
Mutational and expressional alterations of a candidate tumor suppressor HECA gene in gastric and colorectal cancers.
Title: Mutational and expressional alterations of a candidate tumor suppressor HECA gene in gastric and colorectal cancers.
HECA expression is markedly decreased in oral squamous cell carcinoma (OSCC) compared to controls and is associated with decreased sensitivity to cisplatin in OSCC cell lines
Title: The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells.
Human HECA slows down cell division of oral squamous cell carcinoma cells and may therefore act as a tumor suppressor in head and neck cancer.
Title: The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Data show that HECA may be an early-stage classifier of colorectal cancer that can discriminate between late- and early-stage disease.
Title: A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S1787 (e-PCR)
- UniSTS:32029

D6S1522 (e-PCR)
- UniSTS:153891

RH68114 (e-PCR)
- UniSTS:34347

G20423 (e-PCR)
- UniSTS:76337

A005Q40 (e-PCR)
- UniSTS:76338

G29244 (e-PCR)
- UniSTS:66875

AFMa176xf5 (e-PCR)
- UniSTS:72534

RH36066 (e-PCR)
- UniSTS:38636

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory tube development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: headcase protein homolog

Names: headcase homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.