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    Mcm9 minichromosome maintenance 9 homologous recombination repair factor [ Mus musculus (house mouse) ]

    Gene ID: 71567, updated on 12-May-2024

    Summary

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    Official Symbol
    Mcm9provided by MGI
    Official Full Name
    minichromosome maintenance 9 homologous recombination repair factorprovided by MGI
    Primary source
    MGI:MGI:1918817
    See related
    Ensembl:ENSMUSG00000058298 AllianceGenome:MGI:1918817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm235; Mcmdc1; 9030408O17Rik
    Summary
    Enables chromatin binding activity. Involved in DNA repair and female gamete generation. Part of MCM8-MCM9 complex. Is expressed in several structures, including genitourinary system; liver; neural retina; spleen; and telencephalon. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in ovarian dysgenesis 4. Orthologous to human MCM9 (minichromosome maintenance 9 homologous recombination repair factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.4), liver E14 (RPKM 2.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcm9 in Genome Data Viewer
    Location:
    10 B3; 10 27.21 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (53412411..53507251, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (53536315..53630006, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 229B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_26695 Neighboring gene STARR-seq mESC enhancer starr_26696 Neighboring gene STARR-seq mESC enhancer starr_26698 Neighboring gene predicted gene, 40650 Neighboring gene predicted gene, 20597 Neighboring gene STARR-seq mESC enhancer starr_26699 Neighboring gene STARR-positive B cell enhancer ABC_E6844 Neighboring gene STARR-positive B cell enhancer ABC_E10606 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:53349966-53350075 Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene mannosidase 1, alpha Neighboring gene STARR-positive B cell enhancer mm9_chr10:53704763-53705064 Neighboring gene predicted gene, 53584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. Lutzmann M, et al. Cell Rep, 2019 Sep 10. PMID 31509747
    2. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Lutzmann M, et al. Gene, 2005 Dec 5. PMID 16226853
    3. Identification of a novel cell-cycle-induced MCM family protein MCM9. Yoshida K. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850810
    4. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Lutzmann M, et al. Mol Cell, 2012 Aug 24. PMID 22771120
    5. The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. O'Driscoll M. J Pathol, 2017 Jan. PMID 27757957

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
      Title: MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
    2. genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9
      Title: MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.
    3. MCM8 and MCM9 form a complex and that they coregulate their stability.
      Title: MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
    4. Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
      Title: Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
    5. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
      Title: Identification of a novel cell-cycle-induced MCM family protein MCM9.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC70158

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MutLbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MutSbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in recombinational interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM8-MCM9 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM8-MCM9 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA helicase MCM9
    Names
    DNA replication licensing factor MCM9
    mini-chromosome maintenance deficient 9
    mini-chromosome maintenance deficient domain-containing protein 1
    minichromosome maintenance complex component 9
    NP_082106.3
    XP_006512919.1
    XP_006512920.1
    XP_011241508.1
    XP_017169587.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027830.3 → NP_082106.3  DNA helicase MCM9

      Status: VALIDATED

      Source sequence(s)
      AC153949, AC155941
      Consensus CDS
      CCDS23846.2
      UniProtKB/Swiss-Prot
      Q2KHI9, Q3V370, Q6P6J6, Q9D344
      Related
      ENSMUSP00000157761.2, ENSMUST00000237608.2
      Conserved Domains (2) summary
      COG1241
      Location:10 → 605
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      cl25751
      Location:739 → 1004
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      53412411..53507251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314098.3 → XP_017169587.1  DNA helicase MCM9 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:384 → 649
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl28901
      Location:30 → 248
      MCM; MCM helicase family

    2. XM_011243206.2 → XP_011241508.1  DNA helicase MCM9 isoform X2

      See identical proteins and their annotated locations for XP_011241508.1

      Conserved Domains (2) summary
      PTZ00449
      Location:365 → 630
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl28901
      Location:10 → 229
      MCM; MCM helicase family

    3. XM_006512857.5 → XP_006512920.1  DNA helicase MCM9 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P804
      Related
      ENSMUSP00000151639.3, ENSMUST00000219838.3
      Conserved Domains (1) summary
      COG1241
      Location:10 → 383
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

    4. XM_006512856.5 → XP_006512919.1  DNA helicase MCM9 isoform X3

      UniProtKB/TrEMBL
      A0A1W2P804
      Related
      ENSMUSP00000151893.3, ENSMUST00000218549.3
      Conserved Domains (1) summary
      COG1241
      Location:10 → 383
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

    RNA

    1. XR_380074.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KHI9.2 GenPept UniProtKB/Swiss-Prot:Q2KHI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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