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    ADGRG7 adhesion G protein-coupled receptor G7 [ Homo sapiens (human) ]

    Gene ID: 84873, updated on 2-May-2024

    Summary

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    Official Symbol
    ADGRG7provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G7provided by HGNC
    Primary source
    HGNC:HGNC:19241
    See related
    Ensembl:ENSG00000144820 MIM:612307; AllianceGenome:HGNC:19241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR128
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum (RPKM 18.5), small intestine (RPKM 17.4) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q12.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100609601..100695479)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103315353..103401238)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100328445..100414323)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene transmembrane protein 45A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC124906260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63759 Neighboring gene ABI family member 3 binding protein Neighboring gene Sharpr-MPRA regulatory region 7106

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. Chase A, et al. Haematologica, 2010 Jan. PMID 19797732, Free PMC Article
    2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Fredriksson R, et al. Biochem Biophys Res Commun, 2003 Feb 14. PMID 12565841
    3. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    4. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    5. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An expressed in-frame TRK-fused gene-G-protein-coupled receptor GPR128 is identified in healthy individuals and in patients with myeloproliferative neoplasms.
      Title: TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ14454, FLJ16382, FLJ29035, MGC142011, MGC163260

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G7
    Names
    G-protein coupled receptor 128

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308362.1 → NP_001295291.1  adhesion G-protein coupled receptor G7 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC069223, AK172769, AK295345, DA640995
      Consensus CDS
      CCDS77778.1
      UniProtKB/TrEMBL
      B7Z303, E9PHI0
      Related
      ENSP00000419788.1, ENST00000475887.1
      Conserved Domains (2) summary
      pfam01825
      Location:88 → 126
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:138 → 419
      7tm_4; Olfactory receptor

    2. NM_032787.3 → NP_116176.2  adhesion G-protein coupled receptor G7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_116176.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC069223, AK027360, AK172769
      Consensus CDS
      CCDS2938.1
      UniProtKB/Swiss-Prot
      Q14D94, Q86SQ2, Q96K78
      UniProtKB/TrEMBL
      A1L441
      Related
      ENSP00000273352.3, ENST00000273352.8
      Conserved Domains (2) summary
      smart00303
      Location:383 → 422
      GPS; G-protein-coupled receptor proteolytic site domain
      cd15257
      Location:431 → 737
      7tmB2_GPR128; orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      100609601..100695479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449088.1 → XP_047305044.1  adhesion G-protein coupled receptor G7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      103315353..103401238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348147.1 → XP_054204122.1  adhesion G-protein coupled receptor G7 isoform X1

    2. XM_054348148.1 → XP_054204123.1  adhesion G-protein coupled receptor G7 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96K78.2 GenPept UniProtKB/Swiss-Prot:Q96K78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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